PREVENTION of TYPE 1 DIABETES

[Ted_Hutchinson]

If we understand how Type I diabetes develops we should be able to work out safe ways of preventing this condition.
Type 1 diabetes: a disease of developmental origins
Click the box ⇣ сохранить статью for the FULL TEXT PDF to download to your PC.

The idea that a pathogenic gut flora leads to Type 1 diabetes is supported by this paper
Broad-Spectrum Antibiotic Treatment and Subsequent Childhood Type 1 Diabetes: A Nationwide Danish Cohort Study

Redemption of broad-spectrum antibiotics during infancy is associated with an increased risk of childhood type 1 diabetes in children delivered by cesarian section.

So the kids with a poor starting gut flora (C-section) who went on to use more antibiotic courses during infancy ended up with more Type 1 incidence.
This paper goes into the role of gut flora in Type 1 diabetes in greater detail
The role of the intestinal microbiota in*type*1 diabetes mellitus

• The disease process leading to type*1 diabetes mellitus (T1DM) is, in many cases, initiated during the first few years of life, when the intestinal microbiota undergoes dynamic development
• The available data are insufficient to assess whether alterations in the gut microbiota are involved in the initiation of T1DM
• After the appearance of the first disease-predictive autoantibodies, children who progress to clinical T1DM have a reduced bacterial diversity and a decreased abundance of bacteria that produce butyrate or lactate
• The mechanisms by which intestinal microorganisms might affect the initiation of β‑cell autoimmunity and the progression from seroconversion to clinical disease need to be identified
• Standard operating procedures should be applied for the sampling, handling and storage of stool samples, as well as for DNA extraction, to minimize the effect of technical biases

I'll add another few posts to this thread to explain how vitamin d regulates gut bacteria.

 

[Mugdha]

Type 1 diabetes happens when your immune system destroys cells in your pancreas called beta cells. They're the ones that make insulin. Type 1 diabetes typically presents in childhood or early adult life. Doctors don't know all the things that lead to type 1 diabetes. But they do know your genes play a role.

Prevention may be attempted at three levels:

* In the general childhood population (primary prevention);
* In those at increased genetic risk or with predictive markers of diabetes (secondary prevention); and
* In the attempt to rescue residual beta cell function in the newly diagnosed (tertiary prevention).

 

[Ted_Hutchinson]

We already know that Type 1 diabetes incidence can be reduced by 80% if we ensure from birth babies get 2000iu vitamin d3 daily
Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study

We also know that we can rescue residual beta cell function in the newly diagnosed (tertiary prevention).
Cholecalciferol supplementation improves suppressive capacity of regulatory T-cells in young patients with new-onset type 1 diabetes mellitus – a randomized clinical trial
by providing effective strength vitamin d3 daily to keep vitamin d levels optimal.

We can only expcet vitamin d3 to help if we provide sufficient to ensure it stays freely bioavailable. Indigenous peoples living traditional lives wearing little clothing in equatorial regions get natural amounts of cholecalciferol every day. We simply have to replicate that in Western countries using daily effective strength (equivalent to UVB exposure)
Trouble is you can't make much money from non patentable vitamin d3.
You can get a year's supply of 5000 for less than £10 in the UK and a years supply of 10,000iu for £15 so it's no wonder everyone keeps quite about preventing Type I diabetes prevention and incidence continues to increase at 3-5 % annually., Such a pity no one cares to prevent the preventable.