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Old 04-28-2009, 02:52 AM
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Default distressing hypersensitivity to Tyramine please help !!!

Hello, sorry about the lengthy post but i need help and this appears to be a tricky case. I am a 38 y. o. woman with a healthy lifestyle ( well balanced whole foods diet + daily exercise). My appendix was removed when I was 8 y. o. and my gallbladder was removed when I was 21 y. o. due to the presence of stones. I am otherwise very healthy and lean, i do not take any medication and when I was checked for food allergies it was determined that my only allergy was seafood which of course I avoid.
But about 1 year ago I started noticing that I was reacting violently to foods that are high in Tyramine, like salami, cheese, sauerkraut, marzipan, avocado etc... I have had about 12 attacks in 2 years and the symptoms during the attacks are always the same : about 10 mn after ingesting the culprit food my heart starts racing ( 130 to 150 bpm for 3 to 10 mn) , my blood pressure goes up, I feel very dizzy and nauseous and my whole body starts shaking for about 30 mn, which is usually followed by a light headache.
None of the 7 doctors ( including a neurologist) I've seen so far have ever met someone with this problem, and they couldn't tell me why i started being so sensitive. Usually people reacting to Tyramine are migraine sufferers, which I am not, or are taking antidepressants, which I am not either.
My blood tests results are good except for the bilirubin (a little high) and a bit of adrenal fatigue. So after doing much research I put myself on a low Tyramine diet, which helped me put some weight back on and feel less terrified of eating but doesn�t solve anything.
I haven't had another attack in a month so it confirms the Tyramine theory. The question is why am I all of a sudden so sensitive to Tyramine and why do I have these strange scary symptoms ? Is this a temporary condition ? Please let me know if your symptoms are similar in any way, or if you have ever heard of this type of food sensitivity. Thank you for your time.
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� #2
Old 04-28-2009, 05:04 PM
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I've never heard of this condition!
but because your biliruben is a little high I recommend you try a liver cleanse and you can find out how to do it on the links provided on this page:
The Liver Flush, Kidney and Colon Cleanse and Parasite Detox

Since you are all cleared out of these foods that you think offend you you might want to try to introduce one and only one a time to be sure, if you haven't already done so.

You should read this page:
Tyramine - Wikipedia, the free encyclopedia

and specifically this paragraph:


Metabolism

In humans, if monoamine metabolism is compromised by the use of monoamine oxidase inhibitors (MAOIs) and foods high in tyramine are ingested, a hypertensive crisis can result as tyramine can cause the release of stored monoamines, such as dopamine, norepinephrine, epinephrine. The first signs of this were discovered by a neurologist who noticed his wife, who at the time was on MAOI medication, had severe headaches when eating cheese. For this reason, the crisis is still called the "cheese syndrome," even though other foods can cause the same problem.

Physical effects and pharmacology

A large dietary intake of tyramine (or a dietary intake of tyramine while taking MAO inhibitors) can cause the 'tyramine pressor response,' which is defined as an increase in systolic blood pressure of 30 mmHg or more. The displacement of norepinephrine(noradrenaline) from neuronal storage vesicles by acute tyramine ingestion is thought to cause the vasoconstriction and increased heart rate and blood pressure of the pressor response. In severe cases, adrenergic crisis can occur.
However, if one has had repeated exposure to tyramine, there is a decreased pressor response; tyramine is degraded to octopamine, which is subsequently packaged in synaptic vesicles with norepinephrine(noradrenaline). Therefore, after repeated tyramine exposure, these vesicles contain an increased amount of octopamine and a relatively reduced amount of norepinephrine (noradrenaline). When these vesicles are secreted upon tyramine ingestion, there is a decreased pressor response, as less norepinephrine (noradrenaline) is secreted into the synapse, and octopamine does not activate alpha or beta adrenergic receptors.

Imbalance in these red lined items can cause the symptoms you talk about. Cleanse your liver first and then see how you do. Liver has so much to do with the digestive process and the changes chemicals go through in the gut. If the condition remains then perhaps there is a solution in adding particular enzymes to your diet. If not I would see a classical homeopath as they may be able to get you back in balance over time.
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Old 04-28-2009, 05:18 PM
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Maybe you need monoamine oxidase supplement. I don't even know if one exists or if it would be safe to take but you could look into it further and ask a doctor, You might look around for a Clinical Nutritionist....not a registered dietitian, not the same thing.
Cheese: Chemistry, Physics and ... - Google Book Search
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Old 04-29-2009, 01:44 AM
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Default great tips

Thank you so much Arrowwind09, these are great tips, I really appreciate your help.
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