Steve Martin,PhD at Grouppe Kurosawa advises dissolving curcumin with warm coconut milk on the premise that the lauric acid will convey the curcumin throughout the lymphatic system, taking the curcumin to the various tissues where it can impede cancer.

Anjou, HSI's latest altmed basher, claims that the heavy hitter altmed skeptic,
Abel Pharmboy, insists that curcumin is unproven, and is hardly measurable in a person's blood 3 hours after ingesting it.
He says that no lipid will convey curcumin through the lymphatic system because there is no chemical bond.

Gerry, what do you think? Is Dr Steve blowing smoke?



Of course regardless of the blood or lymphatic content,
curcumin could help protect the digestive tract by contact there.
And lauric acid is noted for it antimicrobial properties.

Abel Pharmboy is an obvious shill for BigPharma, but that doesn't mean that he's incorrect.
He's just paid to concentrate his efforts on debunking altmed.

I dissolve my curcumin in coconut oil and I don't know how it's being transported but
apparently it's making it's way to my joints because all my joint & muscle pain has disappeared.

Iggy,
Have you ever tried Cayenne for those pains? 8)
I don't use curcumin ever, but do use the Cayenne for the
same purpose. Also, the Cayenne raises my metabolism.
You need the 90,000 heat units or higher Cayenne to do it,
available from any good HFStore.

I never take pain medication anymore for my joint pains.

No, I haven't use cayenne in recent years. My pain wasn't bad and I was taking the curcumin as a cancer preventative. The abolition of the pain was a serendipitous happy side effect. My metabolism could use a kick start, however.

I've clashed with the ideas of Martin when I was still a member of Coy's AdvancingBudwigProtocol yahoogroup. He's too eager to get into details without seeing the big picture. As in his advocating glutamate, which I thought would prove useless if the person was not getting enough protein (the glutamate would simply be converted to something else).

Anyway, as far as curcumin is concerned, my comment when he brought it up several months ago (and I was still in that yahoogroup) was Why only now? When will he ever get to know about laetrile, or acetogenins, etc.?

So you should understand that I no longer scrutinize ideas that come from him.

As for curcumin, I still have no knowledge about its mechanisms. All I read about are effects. But I would like to see the pathways before I can get to know what's really going on.

I think I mentioned in this or the "other" forum that curcumin (turmeric) and coconut milk = curry! (And I even like it better with cayenne!)

I'll enjoy my food, thank you.

And I won't take my food in pills. :wink:

Gerry

�The most well-studied growth factor blocked by curcumin is nuclear factor-k B. NF-kB is activated by chemical messengers known as cytokines. Cytokines help the immune system, but they also activate signals that tell cells to multiply, grow. By interfering with those signals, curcumin effectively stops the growth of cancer cells by kinase pathways. It has been demonstrated, for example, that curcumin can prevent the bug that causes ulcers (Helicobacter pylori) from causing cancer. H. pylori increases levels of a cytokine (IL-8) that activates NF-kB. Curcumin blocks the process.�

Curcumin is a natural COX-2 inhibtor which works in conjuction with ECGC to fight prostate cancer.

Let me piggyback off of Iggy's initial post. "Phytosomes" (herbal extracts bound to phospholipids) have been shown to have greater bioavailability than standard herbal extracts.

https://www.indena.com/pdf/ephytosome.pdf

So, that got me thinking ...

1. Mixing an herbal extract with phospholipids may be helpful.

2. Gerry prefers foods to pills - as a means of delivery.

What if someone were to mix some turmeric powder/curcumin with egg yolks, prior to consumption? Might this be a way of increasing the level of curcumin in our system? Or, do you think that the bonding process needs to take place in a manner that mixing would not provide for (like in a labratory setting)?

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I think I'll try dissolving curcumin in CO, then scrambling eggs in that.

Gerry, Have you seen this?

https://houston.myeloma.org/Tumeric.pdf

Snortable Curcumin for Alzheimer's

Iggy, and Arrowwind, I posted about the curcumin, coconut oil, here:

comment on Abel Pharmboy's comments about curcumin and coconut oil

"The cells lining the human small intestine contain several types of enzymes that convert curcumin into relatively inactive substances:

UGT (UDP-glucuronosyltransferase) enzymes;
sulfotransferase enzymes;
alcohol dehydrogenase;
p450 enzymes.

These same enzymes are also found in the liver and other tissues.

Among the available substances that inhibit these enzymes are:

Piperine (extracted from black pepper) inhibits UGT enzymes and p450 enzymes;
Quercetin (extracted from various plants) inhibits sulfotransferase enzymes;
Genistein (extracted from soy) inhibits alcohol dehydrogenase

https://www.delano.com/ReferenceArtic...hancement.html

Something else ... just don't know what.

www.research.ucla.edu/tech/ucla06-491.htm

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I will go ahead and quote the full post here:
---------------------
Abel Pharmboy is right that the curcumin will not go primarily to the lymphatics, but not for the reason he states.

Coconut oil is mainly MCT (Medium Chain Triglycerides). MCTs are metabolized differently than LCTs.

https://mywebpages.comcast.net/swaney.../Lipids/p4.htm
and this:
The Science and Practice of Nutrition Support: A Case-based Core Curriculum
and according to our resident Phd Biochemist, Skepzilla:
curcumin is oil-soluble. and if you look at pubmed, you will see studies where the bioavailability of substances changes depending on the type of oil used (MCT or LCT mainly).

here is one:

The fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs.

Interesting info. kitty cat. It seems as though the study, on quercetin and MCTs, indicates that simply taking fats at the same time as the quercetin (instead of necessarily mixing the two together) increases the absorption. Perhaps mixing them prior to consumption would provide an additional benefit though. Generally speaking, solubility aids with absorption.

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I know... I noticed that too. didn't even mix the two. just fed it together.

I think Abel is all wet on curcumin and coconut oil (a little pun - oil and water.. :P )

Another way to enhance bioavailibility is through the fermentation process. Swanson Vitamins carries a product from Japan that contains fermented curcumin.

https://www.swansonvitamins.com/Produ...atalogId=10051

I wonder if we added curcumin to a coconut-based (homemade) yogurt ... that might provide an even greater effect?

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