Cocaine Desire May Be Reduced through Supplementation with N-Acetylcysteine
In this double-blind, placebo-controlled, crossover study involving 15 non-treatment-seeking cocaine-dependent subjects (8 women, 7 men; mean age: 37.4 years), supplementation with N-acetylcysteine (NAC) was found to reduce desire for and interest in cocaine.
"In sum, the reduced subjective reports of desire to use and interest in cocaine indicate that N-acetylcysteine may be a promising new treatment and that cysteine-glutamate exchange may be a potential pharmacotherapeutic target for treating cocaine dependence." Additional research is warranted.
Unfortunately, they chose to employ a poor study-design. Still, it may be better than nothing (especially when looked at in the context of the previous study - above)
N-Acetylcysteine Supplementation Found to be Safe and Well Tolerated in Cocaine-Dependent Subjects Summary: In a pilot study involving 23 subjects with cocaine dependency, N-acetylcysteine (NAC) supplementation was found to be safe, well tolerated, and effective at reducing cocaine dependency.
Subjects seen in an outpatient setting were treated with NAC at doses of 1,200 mg/d, 2,400 mg/d, and 3,600 mg/d, for a period of 4 weeks. All three doses were well tolerated.
Supplementation with the higher doses of NAC (2400 mg/d and 3600 mg/d) was associated with greater retention, suggesting greater effectiveness of the higher doses.
A significant reduction in cocaine use or a complete termination of cocaine use was found in the majority of the subjects (n=16) who completed the study.
The authors conclude, "Overall the findings suggest that it is feasible to treat cocaine-dependent treatment seekers with N-acetylcysteine on an outpatient basis." The promising results of this pilot study warrant further research.