Very interesting...
Quote:
Viral manipulation of DNA repair and cell cycle checkpoints.
Chaurushiya MS, Weitzman MD.
<H3 class=label>Source</H3>Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
<H3>Abstract</H3>Recognition and repair of DNA damage is critical for maintaining genomic integrity and suppressing tumorigenesis. In eukaryotic cells, the sensing and repair of DNA damage are coordinated with cell cycle progression and checkpoints, in order to prevent the propagation of damaged DNA. The carefully maintained cellular response to DNA damage is challenged by viruses, which produce a large amount of exogenous DNA during infection. Viruses also express proteins that perturb cellular DNA repair and cell cycle pathways, promoting tumorigenesis in their quest for cellular domination. This review presents an overview of strategies employed by viruses to manipulate DNA damage responses and cell cycle checkpoints as they commandeer the cell to maximize their own viral replication. Studies of viruses have identified key cellular regulators and revealed insights into molecular mechanisms governing DNA repair, cell cycle checkpoints, and transformation.
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Bill Sardi says '[t]his corroborates with what some researchers think, that cancer gets started by infection of some sort.'
And: 'People who are diagnosed with cancer often describe a history of some sort of wound repair or infection prior to the detection of their cancer.'
Beginnings of Cancer Traced to a Shortage of DNA Spare Parts
Linear Mode
