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\r\n \r\n Objective This study aims to evaluate a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea.
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\n Methods Forty-six patients affected by stage I�III rosacea entered this double-blind, placebo-controlled study. Subjects were treated for 1 month. Clinical and instrumental evaluations were done at baseline, after 10 and 20 days, and at the end of the study. Itching, stinging, erythema, and papules were investigated clinically as well as hydration and erythema instrumentally with capacitance and color measurements.
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\n Results A statistically significant improvement was observed in many clinical and instrumental parameters investigated (P < 0.001). In particular, improvement of skin redness, papules, itching, hydration, and skin color occurred.
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\n Conclusions The combination of silymarin and S-MSM can be useful in managing symptoms and condition of rosacea skin, especially in the rosacea subtype 1 erythemato-telangiectatic phase. The action can be considered multicentric and multiphase because of the direct modulating action on cytokines and angiokines normally involved and up-regulated in the case of such skin condition.\r\n \r\n
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https://www.blackwell-synergy.com/doi...5.2008.00355.x\r\n
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\r\n \r\n very interesting. i will have to try this.
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\nhowever, my rosacea is very mild. it was progressing years ago, until I accidently \'cured\' myself with mangos. ate a bunch of them after talking my husband into peeling them (because I am very allergic to the sap)... and enjoyed them for a week. but.. i guess there must have been some sap somewhere, because my face blew up, I got pick/red circles around my eyes.. I looked like the girl transforming in cat people. my son loved it.. he thought it was cool that I was turning into an alien.
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\nwell, my face finally returned to normal (after a couple of weeks).. and my skin was beautiful. and I didn\'t have rosacea for a couple of years. but.. i notice a little lately.
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\nwell.. spring is almost here.
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\nwhen is mango season? \r\n
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Default Rosacea - Topical Milk Thistle and MSM
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Objective This study aims to evaluate a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea.


Methods Forty-six patients affected by stage I�III rosacea entered this double-blind, placebo-controlled study. Subjects were treated for 1 month. Clinical and instrumental evaluations were done at baseline, after 10 and 20 days, and at the end of the study. Itching, stinging, erythema, and papules were investigated clinically as well as hydration and erythema instrumentally with capacitance and color measurements.

Results A statistically significant improvement was observed in many clinical and instrumental parameters investigated (P < 0.001). In particular, improvement of skin redness, papules, itching, hydration, and skin color occurred.

Conclusions The combination of silymarin and S-MSM can be useful in managing symptoms and condition of rosacea skin, especially in the rosacea subtype 1 erythemato-telangiectatic phase. The action can be considered multicentric and multiphase because of the direct modulating action on cytokines and angiokines normally involved and up-regulated in the case of such skin condition.
https://www.blackwell-synergy.com/doi...5.2008.00355.x
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