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Old 06-29-2010, 06:21 AM
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Default Resveratrol May Boost Eye Health Study

https://www.nutraingredients.com/Rese...letter%2BDaily
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The vascular benefits of resveratrol – a compound found in red wine, blueberries and peanuts – may extend to reducing the risk of blindness for diabetics and seniors, says a new study.

According to findings published in the American Journal of Pathology, resveratrol could reverse the abnormal formation of blood vessels in the retina of mice subjected to a laser treatment

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Old 06-29-2010, 06:56 AM
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Resveratrol, a powerful polyphenol and anti-fungal chemical...
Hold on. Anti-fungal? I did not know that. I knew that it is an anti-inflammatory, which should make it good for arthritis. Also anti-cancer and and protection against Alzheimer�s. I'll have to research more. Thanks liverock.

Quote:
Apte stressed that the animal model of macular degeneration they used is not the same as the human version of the disease, Furthermore, the mice received large resveratrol doses, he said, much more than would be found in several bottles of red wine. If resveratrol is to be effective in people, said Apte, it would need to be given in pill form because of the high doses required.
I know we are not rats; but this is promising. I wonder what dosage would be required for humans, and for how long.
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Old 06-29-2010, 10:43 AM
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I've know for a long time now that Blueberries (Bilberries) were good for the eyes. Many supplements include them, did not relate them to Resveratrol though. Been taking Lutein supplements only, maybe I should switch back to the Bilberry...thanks Liverock!
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Old 06-29-2010, 04:23 PM
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Originally Posted by jfh View Post
Hold on. Anti-fungal? I did not know that. I knew that it is an anti-inflammatory, which should make it good for arthritis. Also anti-cancer and and protection against Alzheimer’s. I'll have to research more. Thanks liverock.

I know we are not rats; but this is promising. I wonder what dosage would be required for humans, and for how long.
If your going to try resveratrol make sure it is TRANS resveratrol which is the more effective type over the cheaper cis resveratrol. 1 X 200mg/day is the normal dosage, which has shown to be the most effective in studies done on resveratrol and various health problems.

https://www.ncbi.nlm.nih.gov/pubmed/15974442

https://www.iherb.com/Now-Foods-Natur...aps/16093?at=0
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Old 06-29-2010, 08:10 PM
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Great minds really do think alike. I bookmarked that iHerb product earlier this morning after reading your starting thread. It is on my list for my next order. Thanks again. Good to know that 200mg will be beneficial.
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Old 08-02-2010, 11:59 AM
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Growth-stimulatory effect of resveratrol in human cancer cells.
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Earlier studies have shown that resveratrol could induce death in several human cancer cell lines in culture.
Here we report our observation that resveratrol can also promote the growth of certain human cancer cells when they are grown either in culture or in athymic nude mice as xenografts.
At relatively low concentrations (</=5 microM), resveratrol exerted a significant growth-stimulatory effect in the MDA-MB-435s human cancer cells, but this effect was not observed in several other human cell lines tested.

Analysis of cell signaling molecules showed that resveratrol induced the activation of JNK, p38, Akt, and NF-kappaB signaling pathways in these cells.

Further analysis using pharmacological inhibitors showed that only the NF-kappaB inhibitor (BAY11-7082) abrogated the growth-stimulatory effect of resveratrol in cultured cells.
In athymic nude mice, resveratrol at 16.5 mg/kg body weight enhanced the growth of MDA-MB-435s xenografts compared to the control group, while resveratrol at the 33 mg/kg body weight dose did not have a similar effect.

Additional analyses confirmed that resveratrol stimulated cancer cell growth in vivo through activation of the NF-kappaB signaling pathway.

Taken together, these observations suggest that resveratrol at low concentrations could stimulate the growth of certain types of human cancer cells in vivo.

This cell type-specific mitogenic effect of resveratrol may also partly contribute to the procarcinogenic effect of alcohol consumption (rich in resveratrol) in the development of certain human cancers
Copyright (c) 2010 Wiley-Liss, Inc
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Old 08-06-2010, 03:11 PM
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The cells used in this study MDA-MB-435, are breast cancer cells and unfortunately resveratrol has a bit of a schizophrenic attitude to the many different types of BC cells.

Resveratrol is a phytoestrogen and appears to have a dual effect on estrogen receptors when faced with different types of BC cells. It can antagonise estrogen in some receptors when faced with one type of BC cell and increase estrogen when faced with a different type of BC cell.

This could account for it protecting against some types of cancer cells and on the other hand, allowing an increase in BC cells in other types of BC cancer cells.

In this respect it acts rather like like the drug tamoxifen which is effective against BC but can cause an increase in cancer of the uterus.

https://www.pnas.org/content/94/25/14138.full

Resveratrol produced greater maximal transcriptional activation than estradiol, but this superagonism was not seen in all cell types. For example, resveratrol produced two to four times greater activation of reporter plasmids than estradiol in MCF-7 breast cancer cells but less activation than estradiol in BG-1 ovarian carcinoma cells. These cell type-specific effects of resveratrol are reminiscent of the well known tissue-specific and species-specific effects of agents such as tamoxifen (27), which can act as an estrogen receptor agonist in some tissues such as the uterus but acts as an estrogen antagonist in the breast (27). Other recently characterized estrogen receptor ligands such as raloxifene also appear to exert tissue-selective actions (28).


https://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/

Estrogenic and Anti-estrogenic Activities

Endogenous estrogens are steroid hormones synthesized by humans and other mammals; these hormones bind to estrogen receptors within cells. The estrogen-receptor complex interacts with unique sequences in DNA (estrogen response elements; EREs) to modulate the expression of estrogen-responsive genes (17). A compound that binds to estrogen receptors and elicits similar responses to endogenous estrogens is considered an estrogen agonist, while a compound that binds estrogen receptors but prevents or inhibits the response elicited by endogenous estrogens is considered an estrogen antagonist. The chemical structure of resveratrol is very similar to that of the synthetic estrogen agonist, diethylstilbestrol (see figure 2), suggesting that resveratrol might also function as an estrogen agonist. However, in cell culture experiments resveratrol acts as an estrogen agonist under some conditions and an estrogen antagonist under other conditions (18, 19). In estrogen receptor-positive breast cancer cells, resveratrol acted as an estrogen agonist in the absence of the endogenous estrogen, 17beta-estradiol, but acted as an estrogen antagonist in the presence of 17beta-estradiol (20, 21). At present, it appears that resveratrol has the potential to act as an estrogen agonist or antagonist depending on such factors as cell type, estrogen receptor isoform (ER alpha or ER beta), and the presence of endogenous estrogens (17).

Retailers of resveratrol normally point out that women who have breast cancer or who have had it should not take resveratrol.

Last edited by liverock; 08-07-2010 at 08:43 AM.
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