Vitamin K and Postmenopausal Women

Harry Hirsute · #1 10-22-2008, 10:36 AM

This may just be a fluke. But, it's something to be mindful of. Some women use vitamin K to support bone health.

Quote:

1: Eur J Nutr. 2008 Oct;47(7):375-9. Epub 2008 Sep 17.

Six weeks phylloquinone supplementation produces undesirable effects on blood lipids with no changes in inflammatory and fibrinolytic markers in postmenopausal women.

Kristensen M, Kudsk J, Bügel S.

Dept. of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, 1958, Frederiksberg C, Denmark. [email protected]

BACKGROUND: Cardiovascular disease is the major cause of death in the Western world, but some recent studies indicate that vitamin K may play a role in atherosclerosis protection.

AIM OF STUDY: The aim of this study was to evaluate the effect of phylloquinone supplementation on blood lipids, inflammatory markers and fibrinolytic activity in postmenopausal women.

METHODS: Thirty-one postmenopausal women completed this placebo-controlled, randomized crossover study and received 500 microg phylloquinone or placebo in addition to their habitual diet during two periods of 6 weeks' duration. Blood concentration of lipids, inflammatory markers and fibrinolytic parameters were measured after each period.

RESULTS: Inflammatory markers, fibrinolytic parameters, total cholesterol and LDL-C were unaffected by the supplementation, whereas a 15% increase was seen in triacylglycerols (P = 0.015) and a 5% decrease in HDL-C (P = 0.06).

CONCLUSIONS: Six weeks supplementation with a dose of phylloquinone similar to that obtainable from the diet induced a deterioration of the lipid profile with no improvement in any of the other risk markers analysed. Thus, these results do not support a cardioprotective effect of vitamin K as has been suggested by others.

https://www.docguide.com/news/content..._uids=18807108

Arrowwind09 · #2 10-22-2008, 06:10 PM

What I want to know now is who funds these guys?

Dept. of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, 1958, Frederiksberg C, Denmark. [email protected]

I think I will continue with my vitamin K until I see more.

Harry Hirsute · #3 10-22-2008, 07:11 PM

Quote:

Originally Posted by Arrowwind09

What I want to know now is who funds these guys?

Dept. of Human Nutrition, Centre for Advanced Food Studies, University of Copenhagen, Rolighedsvej 30, 1958, Frederiksberg C, Denmark. [email protected]

I think I will continue with my vitamin K until I see more.

I don't know who funds them. I would assume it's government funded. But, I could be wrong.

I've advised my wife and mother to take vitamin K. I have no intention, at this point, to change that advice. Of course, they're taking the MK7 form of vitamin K (K2 not K1, like that which was used in this study).

Both my wife and my mother have very high HDL and very low triglycerides.

Still, this research is something to keep in mind. If, for no other reason, to disprove it.

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