Vitamin K2 for Rheumatoid Arthritis


...elusive dreamer
Apr 5, 2009
More information about the use of K2 for rheumatoid arthritis.

Vitamin K2 Effective in Rheumatoid Arthritis

Posted on:
Friday, July 7th 2017 at 1:00 pm
Written By:
Dr. Michael Murray

Originally published on

Just as there has been an explosion of positive science on the importance of vitamin D3, another nutrient, vitamin K2, is showing tremendous promise in the treatment and prevention of a wide range of health conditions.

A new study, set to be published in the August issue of the European Journal of Pharmacology, indicates that this underutilized form of vitamin K might hold the key to one of the most debilitating inflammatory conditions known to humans – rheumatoid arthritis.

Background Data:
Rheumatoid arthritis (RA) is a chronic inflammatory condition that affects the entire body, but especially the joints. There is abundant evidence that RA is an autoimmune reaction, in which antibodies develop against components of joint tissues, but what exactly triggers this autoimmune reaction has centered on genetic factors, abnormal bowel permeability, lifestyle and nutritional factors, food allergies, and microorganisms. RA is a classic example of a multifactorial disease, wherein an assortment of genetic, dietary, and environmental factors contribute to this disease.

There are several forms of vitamin K. Phylloquinone is derived from plant sources and is referred to as K1, whereas menaquionines are derived primarily from bacteria and are referred to a K2. There are several different forms of menaquinones based upon the number of attached molecules known as isoprenoids. MK-7 is the most important commercial form of vitamin K2. It contains seven isoprenoid residues attached to menaquinone.

While the role that vitamin K plays in blood clotting is well known, it also functions in important roles for bone and joint health. Clinical studies have documented the long-term effect of 180 mcg of MK-7 in improving bone density and overall bone health.

Based upon pre-clinical studies showing another form of vitamin K2 (MK-4) blocked the development of arthritis in the experimental animal model of RA, it was suggested that MK-4 might offer benefit in human RA. Human studies following and it was shown MK-4 supplementation reduced RA disease activity associated with a marked decrease in clinical and biochemical markers. However, since MK-7 has greater bioavailability than MK-4 after oral administration, researchers were quite curious if even better results might be produced with this form.