endothelial function COPD


Active member
May 25, 2009
Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

"Due to elevated cardiovascular disease risk associated with lung disease, there is emerging interest in conducting clinical trials that target vascular health outcomes in patients with COPD.
The present study not only supports within-day, but also between-day reproducibility of vascular health assessments using FMD and arterial tonometry in patients with COPD.
These findings are particularly important when evaluating the potential mechanisms that contribute to cardiovascular disease risk in COPD, either in a single testing day or over a longer treatment period.

Patients with COPD present a high risk of cardiovascular disease associated with the disturbance of the vascular endothelium.2,7,18 Local inflammation in respiratory airways induces the over production of reactive oxygen species, chemokines, and cytokines which evoke a systemic perturbation that reduces nitric oxide bioavailability and contributes to systemic vascular dysfunction.

In fact, the degree of endothelial impairment is not only related with disease severity assessed by FEV1 (% predicted), but is also associated with a worse overall prognosis."

Relevant to the maintenance of endothelial function is DAILY CHOLECALCFERIOL Supplmenation sufficient to keep 25(OH)D levels at/above the natural level for human DNA 125nmol/l (50ng/mL)

Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium.