Originally Posted by jfh
Ted, you introduced a D3 soft gel 10,000IU. I absolutely believe in soft gel or liquid. I have the same brand in 5000IU. I'm taking 2 daily; but one in the morning and one in the afternoon would be better than one large one each day. Am I right? I do this with herbs and vitC, thinking that I would be better saturated, if I spread it out.
To be honest there is no evidence to support the idea of spreading D3 intake over the day.
It's fat soluble, has a half life measured in weeks and frankly, apart from pregnant and breastfeeding women it makes very little difference if the dose is daily weekly fortnightly or monthly providing the sum total is adequate to keep levels in the upper 50's lower 70's ng/ml 137.56nmol/l ~175nmol/l.
Taylor, Hollis and Wagner have done the work with Vitamin D in pregnancy and lactation and they insist that DAILY supplemenation for pregnant and nursing mothers is NECESSARY to ensure the baby gets a steady even supply. Do be aware of the Following research paper and keep levels HIGH BUT STABLE. Hollis has shown that 6400iu/daily is required during pregnancy and lactation to ensure breast milk if vitamin D replete and baby is born with Sufficient vitamin d in place to absorb calcium optimally. But there is other work showing from Finland associating higher levels of Vitamin D with breast cancer incidence. (it matches the Finnish Research on High Vitamin D prostate cancer incidence) Finland is way north. People in Finland with high vitamin d tend to have HUGE swings of status from summer to winter and it is the disequilibrium that arises during rapid increases and decreases in 25(OH)D status that is the likely cause.
I've put a copy of Vieth's paper online here because it is so important that people understand the idea of keeping your levels BOTH HIGH AND STABLE. If you are going to fly South for the Winter Sun then supplement before you go and on the return home but not while you are in the sun. Try and spread the change over a longer period and even out the highs/lows.
I prefer daily supplementing because I've read
How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation and Hydroxylase Enzymology
and want to keep my levels both high and stable and avoid the necessity for my immune function to have to retune itself to rebalance the proliferative/antiproliferative forces.
Having just learnt that Calcidiol 25(OH)D is not just a prohormone but is now regarded as an active hormone in it's own right and one which works collaberatively with 1.25 Calcitriol it seems more important than ever not be be short of this important hormone. Concentrations below 40ng/ml 100nmol/l were shown not to have any measurable effect on cancer cells so if cancer prevention or treatment is what we are after then HIGHER LEVELS are more likely to have that effect.
Vitamin C on the other hand is WATER SOLUBLE. Once it's absorbed into the body it's half life is measured in minutes. Only ever buy small dose TIME RELEASE SUSTAINED RELEASE TYPES. 1 x 500mg vitamin C time release every 8hrs is better than 1 x 1.5mg vitamin c not time release once daily, even better would be 6 x 250mg every 4hrs through day/night.