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Old 08-24-2007, 11:55 AM
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Default Vitamin E - Higher Dosages May Be Needed

A double-blind randomized placebo-controlled study was performed with 35 volunteers (average age 42, 23 women) to investigate the effects of different doses on plasma F2-isoprostanes concentrations. The volunteers were placebo or 100, 200, 400, 800, 1600, or 3200 IU of vitamin E daily for 16 weeks

The researchers report a dose-dependent effect of vitamin E on the percentage reduction in plasma F2-isoprostane concentrations. Statistical significance of the reduction was achieved with the higher doses, with 1600 IU reducing F2-isoprostane levels by 35 per cent, and 3200 IU of the vitamin producing a 49 per cent reduction.

"It was clear that large doses - and doses in excess of what all clinical studies had used - were necessary," said co-author Jason Morrow.
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