Researchers have found that a new highly absorbableform of magnesium called magnesium-L-threonate concentrates more efficiently in the brain, rebuilds ruptured synapses, and restores the degraded neuronal connections observed in Alzheimer's disease and other forms of memory loss
Both Vitacost and Iherb carry the Life Extension, Neuro-Mag, Magnesium L-Threonate, 90 Veggie Caps : $30.00 although if you are a life Extension member you may do better bulk buying from them. $27
Depending on the discounts/shipping you can get elsewhere.
If you haven't used Iherb/Vitacost before there are $5 or $10 initial discounts available if you pm me or look around.
L-Threonate also helps to prevent DHT buildup. Good to know, if you are balding. Too late for you Saved.
This complex of magnesium and l-threonate is the only magnesium compound that is able to cross the brain barrier, supplying more magnesium to the brain, and can enhance memory.
Learning and memory are fundamental brain functions affected by dietary and environmental factors. Here, we show that increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) leads to the enhancement of learning abilities, working memory, and short- and long-term memory in rats. The pattern completion ability was also improved in aged rats. MgT-treated rats had higher density of synaptophysin-/synaptobrevin-positive puncta in DG and CA1 subregions of hippocampus that were correlated with memory improvement. Functionally, magnesium increased the number of functional presynaptic release sites, while it reduced their release probability. The resultant synaptic reconfiguration enabled selective enhancement of synaptic transmission for burst inputs. Coupled with concurrent upregulation of NR2B-containing NMDA receptors and its downstream signaling, synaptic plasticity induced by correlated inputs was enhanced. Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions. https://www.ncbi.nlm.nih.gov/pubmed/20152124
Begun at MIT, the research started as a part of a post-doctoral project by Dr. Inna Slutsky of TAU's Sackler School of Medicine and evolved to become a multi-center experiment focused on a new magnesium supplement, magnesium-L-theronate (MgT), that effectively crosses the blood-brain barrier to inhibit calcium flux in brain neurons.
Published recently in the scientific journal Neuron, the new study found that the synthetic magnesium compound works on both young and aging animals to enhance memory or prevent its impairment. The research was carried out over a five-year period and has significant implications for the use of over-the-counter magnesium supplements.
In the study, two groups of rats ate normal diets containing a healthy amount of magnesium from natural sources. The first group was given a supplement of MgT, while the control group had only its regular diet. Behavioral tests showed that cognitive functioning improved in the rats in the first group and also demonstrated an increase of synapses in the brain � connective nerve endings that carry memories in the form of electrical impulses from one part of the brain to the other.
Bad news for today's magnesium supplements
"We are really pleased with the positive results of our studies," says Dr. Slutsky. "But on the negative side, we've also been able to show that today's over-the-counter magnesium supplements don't really work. They do not get into the brain.
"We've developed a promising new compound which has now taken the first important step towards clinical trials by Prof. Guosong Liu, Director of the Center for Learning and Memory at Tsinghua University and cofounder of Magceutics company," she says.
While the effects were not immediate, the researchers in the study � from Tel Aviv University, MIT, the University of Toronto, and Tsighua University in Beijing � were able to assess that the new compound shows improved permeability of the blood-brain barrier. After two weeks of oral administration of the compound in mice, magnesium levels in the cerebral-spinal fluid increased.