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Short-Term Hyperinsulinemia and Hyperglycemia Increase \r\n
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\r\n \r\n \r\n \r\n Increased myocardial lipid content (MYCL) recently has been linked to the development of cardiomyopathy in diabetes.
\n In contrast to steatosis in skeletal muscle and liver, previous investigations could not confirm a link between MYCL and insulin resistance.
\n Thus, we hypothesized that cardiac steatosis might develop against the background of the metabolic environment typical for prediabetes and early type 2 diabetes: combined hyperglycemia and hyperinsulinemia.
\n Therefore, we aimed to prove the principle that acute hyperglycemia (during a 6-h clamp) affects MYCL and function (assessed by (1)H magnetic resonance spectroscopy and imaging) in healthy subjects (female subjects: n = 8, male subjects: n = 10; aged 28 � 5 years; BMI 22.4 � 2.6 kg/m(2)).
\n Combined hyperglycemia (202.0 � 10.6 mg/dL) and hyperinsulinemia (110.6 � 59.0 μU/mL) were, despite insulin-mediated suppression of free fatty acids, associated with a 34.4% increase in MYCL (baseline: 0.20 � 0.17%, clamp: 0.26 � 0.22% of water signal; P = 0.0009), which was positively correlated with the area under the curve of insulin (R = 0.59, P = 0.009) and C-peptide (R = 0.81, P < 0.0001) during the clamp.
\n Furthermore, an increase in ejection fraction (P < 0.0001) and a decrease in end-systolic volume (P = 0.0002) were observed, which also were correlated with hyperinsulinemia.
\n Based on our findings, we conclude that combined hyperglycemia and hyperinsulinemia induce short-term myocardial lipid accumulation and alterations in myocardial function in normal subjects, indicating that these alterations might be directly responsible for cardiac steatosis in metabolic diseases.\r\n \r\n | \r\n
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Plain English version from Science Daily.
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One Cause of Fatty Deposits in the Hearts of Diabetes Patients Settled\n
\nI think this quote from Michael Krebs from
the Diabetes UK article is important
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\r\n \r\n | \r\n \r\n The first diagnosis usually occurs by accident and on average five years too late. Our data show that the foundation for damage can be laid early on, especially in patients with high blood sugar and hyperinsulinemia – an elevated insulin level – during prediabetes and early diabetes.\r\n \r\n | \r\n
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We can do something about that NOW by lowering our refinedcarb/sugar intakes and improving our anti inflammatory Vitamin D3, Magnesium, Omega 3 and Melatonin levels. We can predict from
25(OH)D and
Magnesium status those who are going to become Diabetic before they finally become Vitamin D, magnesium depleted and diagnosed diabetic. The cost of 5000iu D3 is �10 yearly and magnesium albion chelates are not that expensive
\nIf you live in the UK and want to know the cheapest sources of Healthy Origins 5000iu Vitamin D3 Drops or Source Naturals magnesium pm me.\r\n
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\r\n\r\n One Cause of Fatty Deposits in the Hearts of Diabetes Patients Settled\r\n 
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