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Old 12-12-2007, 11:46 AM
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Default Coffee May Raise Adiponectin and Lower Inflammation

To test whether the beneficial effects of coffee consumption in metabolism might be explained by changes in circulating levels of adiponectin, we evaluated self-reported habitual coffee and tea consumption and caffeine intake as predictors of plasma adiponectin concentrations among 982 diabetic and 1058 non-diabetic women without cardiovascular disease from the Nurses' Health Study.

Women with and without diabetes who drank >/=4 cups of coffee per day had significantly higher adiponectin concentrations than those who didn't drink coffee regularly (7.7mug/ml vs. 6.1mug/ml, P=0.004; 15.0mug/ml vs. 13.2mug/ml in non-diabetics, P=0.04). Similar associations were observed for caffeine intake.

We confirm previously reported inverse associations of coffee consumption with inflammatory markers, C-reactive protein and TNF-alpha receptor II.

Adjustment for adiponectin did not weaken these associations, nor did adjustment for inflammatory markers attenuate the association between coffee consumption and adiponectin.

High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.

What is adiponectin?
Adiponectin: A protein hormone produced and secreted exclusively by adipocytes (fat cells) that regulates the metabolism of lipids and glucose. Adiponectin influences the body's response to insulin. Adiponectin also has antiinflammatory effects on the cells lining the walls of blood vessels.

High blood levels of adiponectin are associated with a reduced risk of heart attack. Low levels of adiponectin are found in people who are obese (and who are at increased risk of a heart attack).

Adipocytes produce and secrete a number of proteins, including leptin, adipsin, properdin, and tumor necrosis factor (TNF). An adipose tissue-specific factor was isolated and termed APM1 (AdiPose Most abundant gene transcript 1). The protein product of APM1 is adiponectin. The APM1 gene maps to chromosome 3q27.
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