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Old 12-26-2007, 07:40 PM
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Default Green Tea + Turmeric May Combat Breast Cancer

Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer.

This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination.

Studies in MDA-MB-231 cells demonstrated that EGCG + curcumin was synergistically cytotoxic and that this correlated with G(2)/M-phase cell cycle arrest. After 12 hr, EGCG (25 muM) + curcumin (3 muM) increased the proportion of cells in G(2)/M-phase to 263 +/- 16% of control and this correlated with a 50 +/- 4% decrease in cell number compared to control.

To determine if this in vitro result would translate in vivo, athymic nude female mice were implanted with MDA-MB-231 cells and treated with curcumin (200 mg/kg/day, po), EGCG (25 mg/kg/day, ip), EGCG + curcumin, or vehicle control (5 ml/kg/day, po) for 10 weeks.

Tumor volume in the EGCG + curcumin treated mice decreased 49% compared to vehicle control mice (p < 0.05), which correlated with a 78 +/- 6% decrease in levels of VEGFR-1 protein expression in the tumors.

Curcumin treatment significantly decreased tumor protein levels of EGFR and Akt, however the expression of these proteins was not further decreased following combination treatment.

Therefore, these results demonstrate that the combination of EGCG and curcumin is efficacious in both in vitro and in vivo models of ERalpha- breast cancer and that regulation of VEGFR-1 may play a key role in this effect.
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Old 08-25-2009, 11:52 AM
t-b t-b is offline
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Default turmeric benefits

Hey, do you have any other information about claimed turmeric benefits?

Last edited by t-b; 08-28-2009 at 11:36 AM.
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Old 08-25-2009, 12:55 PM
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On this page https://www.turmeric-curcumin.com/
go to the section that has links to numerous studies. The subtitle is: Recent news and published studies on Curcumin and Turmeric

You will be surprised.
- Jim
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Old 08-25-2009, 03:40 PM
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Turmeric has so many benefits that the drug companies are getting worried. They are coming up with synthetic curcuminoids since there is no money in supplying turmeric capsules
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Old 03-26-2010, 02:15 PM
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EGCG is also a dopa decarboxalse inhibitor, meaning less dopamine conversion.
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