11-09-2007, 03:26 PM
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Lecturer
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Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,852
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Lycopene and Colorectal Cancer
Quote:
Background: Higher circulating insulin-like growth factor I (IGF-I) concentrations have been related to a greater risk of cancer.
Lycopene intake is inversely associated with cancer risk, and experimental studies have shown that it may affect the IGF system, possibly through an effect on IGF-binding proteins (IGFBPs).
Design: We conducted a randomized, placebo-controlled, double-blinded crossover study in 40 men and 31 postmenopausal women with a family history of colorectal cancer, a personal history of colorectal adenoma, or both.
Results: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%).
Serum IGFBP-2 concentrations were higher in both men and women after lycopene supplementation than after placebo, but to a lesser extent (mean relative difference 8.2%; 95% CI: 0.7%, 15.6% in men and 7.8%; 95% CI: �5.0%, 20.6% in women).
Total IGF-I, IGF-II, and IGFBP-3 concentrations were not significantly altered by lycopene supplementation.
Conclusions: This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations. Because of high interindividual variations in IGFBP-1 and IGFBP-2 effects, these results should be confirmed in larger randomized intervention studies.
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https://www.ajcn.org/cgi/content/abstract/86/5/1456
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