Introducing a 'glucose sensor' by gene therapy eliminates the symptoms of the disease
Researchers from the Universitat Aut�noma de Barcelona (UAB), led by F�tima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. As published this week in Diabetes, the principal journal for research on the disease, after a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease. In some cases, monitoring continued for over four years, with no recurrence of symptoms.
The therapy is minimally invasive. It consists of a single session of various injections in the animal's rear legs using simple needles that are commonly used in cosmetic treatments. These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other. Glucokinase is an enzyme that regulates the uptake of glucose from the blood. When both genes act simultaneously they function as a "glucose sensor", which automatically regulates the uptake of glucose from the blood, thus reducing diabetic hyperglycemia (the excess of blood sugar associated with the disease).
As F�tima Bosch, the head researcher, points out, "this study is the first to demonstrate a long-term cure for diabetes in a large animal model using gene therapy."
This same research group had already tested this type of therapy on mice, but the excellent results obtained for the first time with large animals lays the foundations for the clinical translation of this gene therapy approach to veterinary medicine and eventually to diabetic patients.
The study was led by the head of the UAB's Centre for Animal Biotechnology and Gene Therapy (CBATEG) F�tima Bosch, and involved the Department of Biochemistry and Molecular Biology of the UAB, the Department of Medicine and Animal Surgery of the UAB, the Faculty of Veterinary Science of the UAB, the Department of Animal Health and Anatomy of the UAB, the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), the Children's Hospital of Philadelphia (USA) and the Howard Hughes Medical Institute of Philadelphia (USA).
The study provides ample data showing the safety of gene therapy mediated by adeno-associated vectors (AAV) in diabetic dogs. The therapy has proved to be safe and efficacious: it is based on the transfer of two genes to the muscle of adult animals using a new generation of very safe vectors known as adeno-associated vectors. These vectors, derived from non-pathogenic viruses, are widely used in gene therapy and have been successful in treating several diseases.
In fact, the first gene therapy medicine ever approved by the European Medicines Agency, named Glybera�, makes use of adeno-associated vectors to treat a metabolic disease caused by a deficiency of lipoprotein lipase and the resulting accumulation of triglycerides in the blood.
Long-term control of the disease
Dogs treated with a single administration of gene therapy showed good glucose control at all times, both when fasting and when fed, improving on that of dogs given daily insulin injections, and with no episodes of hypoglycemia, even after exercise. Furthermore, the dogs treated with adeno-associated vectors improved their body weight and had not developed secondary complications four years after the treatment.
The study is the first to report optimal long-term control of diabetes in large animals. This had never before been achieved with any other innovative therapies for diabetes. The study is also the first to report that a single administration of genes to diabetic dogs is able to maintain normoglycemia over the long term (more than 4 years). As well as achieving normoglycemia, the dogs had normal levels of glycosylated proteins and developed no secondary complications of diabetes after more than 4 years with the disease.
Application in diabetic patients
There have been multiple clinical trials in which AAV vectors have been introduced into skeletal muscle, so the strategy reported in this study is feasible for clinical translation. Future safety and efficacy studies will provide the bases for initiating a clinical veterinary trial of diabetes treatment for companion animals, which will supply key information for eventual trials with humans. In conclusion, this study paves the way for the clinical translation of this approach to gene therapy to veterinary medicine, and eventually to diabetic patients.
Diabetes mellitus
Diabetes mellitus is the most common metabolic disease, and a large number of patients need insulin treatment to survive. In spite of the use of insulin injections to control the disease, these patients often develop serious secondary complications like blindness, kidney damage or amputation of limbs. Moreover, in order to achieve good blood glucose control, insulin has to be injected two or three times a day, which brings a risk of hypoglycemia episodes (lowering of blood sugar): an additional problem that comes on top of the other hardships of the treatment.
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- Jim
"I am not young enough to know everything." - Oscar Wilde
Dogs become diabetic for the same reason humans do, and it has absolutely nothing to do with insulin...that is just a symptom... diabetic dogs are deficient in chromium and vanadium same as human type 2 diabetics.
You can cure diabetes in a week using the above two nutrients along with the necessary co-factors found in beyond tangy tangerine or the mighty 90.
These products contain about 77 minerals in colloidal form, that the body craves. Most doctors don't know this, however the people who make snack food sure do... that is why these products are high in salt..
Lets see... supplement so you aren't deficient or remain deficient but mess with gene therapy.....hmmm..tough choice..
Lets see... supplement so you aren't deficient or remain deficient but mess with gene therapy.....hmmm..tough choice..
Since the general population of alternative or naturopathic doctors or clinical labs have not researched supplement deficiency as a cause of diabetes, it is not really a choice except that the gene modification has been tested and proven.
Beyond tangy tangerine is a concentrated powder product that contains 115 fruits and vegetables, along with a complete multivitamin, with an ORAC score of over 5700 per serving. ( most people get less than 1500 per day)
This product also contains the 60+ minerals that are essential for life, in optimal amounts.
The "mighty 90" refers to the 90 essential nutrients required by the body on a daily basis. (16 vitamins, 60 minerals, 12 amino acids, and 3 essential fatty acids)
Dogs become diabetic for the same reason humans do, and it has absolutely nothing to do with insulin...that is just a symptom... diabetic dogs are deficient in chromium and vanadium same as human type 2 diabetics.
You can cure diabetes in a week using the above two nutrients along with the necessary co-factors found in beyond tangy tangerine or the mighty 90.
These products contain about 77 minerals in colloidal form, that the body craves. Most doctors don't know this, however the people who make snack food sure do... that is why these products are high in salt..
Lets see... supplement so you aren't deficient or remain deficient but mess with gene therapy.....hmmm..tough choice..
Can you do us a huge favor and share with us the exact recommended protocol if you know it?
Can you do us a huge favor and share with us the exact recommended protocol if you know it?
According to all scientific reports, we are at a time in history where top soil is at its lowest, the use of chemicals is at its highest, and the world population has never been higher, at 7 billion+..
Because of the use of chemicals such as roundup, poor farming methods, and using NPK fertilizers, most farm land is depleted of several minerals. Therefor, plants are as well, and thus the veggies that we eat contain little nutrient value. Study after study shows less beta carotene, less vitamin c, vitamin e, less b vitamins, etc., with several trace minerals missing.
Long story short, we are becoming nutrient deficient, especially in minerals, and since most supplements contain minerals in elemental form, they are almost useless... and without these mineral co-factors, vitamins don't work properly. This, over time, is what causes disease.
You can eat all the organic vegetables you want, and it is good that they don't contain pesticides, but that doesn't mean they contain more minerals, since that depends on the soil.
The protocol for good health is to follow a good diet. This means a diet rich in good fats such as coconut oil, fish oil, flax seed oil, borage oil, evening primrose oil, olive oil if it is virgin and fresh, seeds, nuts, and protein from free range animals, chickens, turkey, and eggs... or from plants if you are vegan. Carbs should be limited to complex vegetable carbs, while avoiding the simple refined carbs, the high fructose corn syrup, the artificial sweeteners, the artificial colors and taste boosters such as MSG, limit fast food, processed food, and fried (especially deep fried) food.
Avoid alcohol of any kind or amount, deal with stress on a daily basis rather than all at once, get plenty of sunshine, clean water, unprocessed tea, variety of fruits, and supplement with resveratrol, curcumin, astaxanthin, non GMO ascorbic acid, all 8 forms of vitamin E, extra D3 depending where you live and how much natural sun you get, exercise on a regular basis, don't smoke or do drugs of any kind, and avoid grains, including corn and soy.
There is still one important step to the above protocol, and that is making sure you get all 90 essential nutrients, especially the 60+ minerals. The only sure way of doing this is to take a total mineral complex in colloidal form for best absorption, in optimal amounts.
The idea is to supplement one ounce of this total mineral complex per day per 100 pounds of body weight. Once your body builds up reserves of these trace minerals, food cravings stop, weight falls off without effort, and all kinds of health conditions disappear... all for about $1 per day.
You could take the "beyond tangy tangerine" which contains all 90 nutrients together with 115 vegetable powder, but costs more like $1.50 per day... about the price of a medium coffee..
You can reverse any health condition (or greatly improve it) by giving your body the raw materials that it needs to repair and regenerate, but like my dad used to say, "you can't make a silk purse out of a sow's ear"..
Dogs become diabetic for the same reason humans do, and it has absolutely nothing to do with insulin...that is just a symptom... diabetic dogs are deficient in chromium and vanadium same as human type 2 diabetics.
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I though the article was addressing Type I diabetes?
Quote:
Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. In type 1 diabetes, the body does not produce insulin.
Insulin is a hormone that is needed to convert sugar, starches and other food into energy needed for daily life. Only 5% of people with diabetes have this form of the disease
__________________ "We know that no one ever seizes power with the intention of relinquishing it. Power is not a means; it is an end. One does not establish a dictatorship in order to safeguard a revolution; one makes the revolution in order to establish the dictatorship. The object of persecution is persecution. The object of torture is torture. The object of power is power. Now you begin to understand me." George Orwell
So diabetes is a degenerative disease caused by excessive peaks of insulin, because humans ingest 'food' something as 10-15 times a day (in which I count a simple cookie, for example). To revert this process, we use gene therapy.
Has this any logic? When is the mankind realize that the only way to cure degenerative diseases is to use the inverse process that caused it? If we have heart attacks because we are nutritionally deficient, have too much toxicity in the body, and so on, we want to invert these vectors in order to reverse the disease. That's why organic plant-based diets work on this topic!
UAB researchers CURE type 1 diabetes in dogs
Hybrid Mode
