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Old 11-21-2006, 02:11 PM
nightowl nightowl is offline
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Default Alzheimer's research...interesting

If I understand this correctly, and it's a little hard to follow, mice brains that were depleted of alpha-tocopherol (vitamin E) developed increasing amounts of amyloid beta-peptide deposits. When alpha-tocopherol was supplemented to the mice the amyloid beta-peptides were ameliorated.

I have a sister-in-law with late stage Alzheimer's Disease, so I'm always looking for help for her. It is probably too late for her, but this does sound like they're on the right track.


Study findings from Tokyo Medical and Dental University, Department of Neurology provide new insights into alzheimer disease



Investigators publish new data in the report "Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse. Increased oxidative damage is a prominent and early feature in Alzheimer disease (AD). However, whether it is a primary cause or merely a downstream consequence in AD pathology is still unknown," scientists in Tokyo, Japan report.

"We previously generated alpha-tocopherol transfer protein knockout (Ttpa-/-) mice, in which lipid peroxidation in the brain was significantly increased by complete depletion of alpha-tocopherol (alpha-Toc). Here we crossed AD transgenic (APPsw) model mice (Tg2576) with Ttpa-/-mice. The resulting double-mutant (Ttpa-/-APPsw) mice showed earlier and more severe cognitive dysfunction in the Morris water maze, novel-object recognition, and contextual fear conditioning tests. They also showed increased amyloid beta-peptide (Abeta) deposits in the brain by immunohistochemical analysis, which was ameliorated with alpha-Toc supplementation," wrote Y. Nishida and colleagues, Tokyo Medical and Dental University, Department of Neurology.

The researchers concluded: "In this report we provide clear evidence indicating that chronic lipid peroxidation due to alpha-Toc depletion enhances AD phenotype in a mouse model."

Nishida and colleagues published their study in Biochemical and Biophysical Research Communications (Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse. Biochemical and Biophysical Research Communications, 2006;350(3):530-6).

For additional information, contact Y. Nishida, Graduate School, Dept. of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.

The publisher's contact information for the journal Biochemical and Biophysical Research Communications is: Academic Press Inc. Elsevier Science, 525 B St., Ste. 1900, San Diego, CA 92101-4495, USA.

Keywords: Japan, Tokyo, Alzheimer Disease, Biochemical, Central Nervous System Disease.

This article was prepared by Pain & Central Nervous System Week editors from staff and other reports. Copyright 2006, Pain & Central Nervous System Week via NewsRx.com.
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Old 03-24-2007, 01:57 AM
Harry Hirsute's Avatar
Harry Hirsute Harry Hirsute is offline
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Default Aged Garlic May Prevent Progression

"Feeding of aged garlic extract prevented deterioration of hippocampal based memory tasks in these mice, suggesting that aged garlic extract has a potential for preventing AD progression."

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Old 03-24-2007, 12:22 PM
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Here are a number of supplements that may be helpful:
  • Drink more vegetable and fruit juices, particularly vegetable juices since they have less fructose. These juices have tons of beneficial antioxidants.
  • Exposure to sunlight in the morning and sleep pattern restoration
  • Therapy with B vitamins, such as B6, folic acid, and B12 (methylcobalamin) that lower homocysteine levels. It is thought that a high homocysteine level in the brain causes neuronal damage leading to progression of Alzheimer's disease.
  • The use of antioxidants, such as vitamin E. At this point I would not recommend more than 100 units per day. If you plan to take vitamin E, use a form that has all the tocopherols and tocotrienols. Another very important antioxidant is lipoic acid, at a dose of 10 to 50 mg a few times a week. Many herbs have antioxidant potential including curcumin, acai, goji, mangosteen, etc.
  • Acetyl-L-carnitine protects against amyloid-beta neurotoxicity and may be helpful in combination with medicines. The dose should not be more than 100 to 300 mg a day a few times a week.
  • Providing acetylcholine precursors, such as choline. Maximum dose 100 to 500 mg a few times a week.
  • Use of ginkgo biloba should certainly be considered.
  • Use of curcumin, the yellow compound found in turmeric. Curcumin supplements are now available. Curcumin is lately getting more attention and appears to be a good preventive spice.
  • Blocking the breakdown of acetylcholine with pharmaceutical drugs or natural supplements such as huperzine.
  • People who eat an average of 180 mg or more a day of DHA, a fatty acid found in fish oils, have a lower incidence of Alzheimer's disease and other types of dementia, compared with people who consume less DHA, according to epidemiologic data collected in the Framingham Heart Study. Dietary supplementation with omega-3 fatty acids may protect cognitive function in patients with mild, early stage AD.
  • Improving blood flow to brain cells
  • Mood improvement through nutrients and herbs
  • Drinking herbal teas, including green tea
  • Hormone therapies with testosterone and DHEA -- maybe. Caution is advised.
  • Muira puama, a Brazilian plant used for sexual enhancement, may have acetylcholinesterase inhibiting activity.
  • A high concentration of silica in drinking water seems to protect against Alzheimer's disease
    Blue Green Algae has a cholinesterase inhibitor
  • Sage contains several cholinesterase inhibitors and could help Alzheimer's disease.
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