I'm familiar with Pantothenic Acid, and though this short article was interesting...
Pantethine vs. Pantothenic Acid
Pantothenic Acid is the beta alanine amide of pantoic acid. A growth substance
widely distributed in plant and animal tissues, and essential for growth of a
number of organisms; dietary deficiency causes dermatitis in chicks, and
dermatitis and achromotrichia in rats; Pantothenic Acid is a precursor to
Pantethine is a dietary supplement that is related to vitamin B5 (pantothenic
acid). Pantethine is used for lowering cholesterol, preventing inflammation,
boosting the activity of the immune system, treating an inherited condition
called cystinosis, treating gastrointestinal (GI) diseases, and improving
athletic performance. It is also used for improving energy, lowering the risk of
heart attack and stroke, improving adrenal function, protecting against mental
and physical stress, and preventing allergy symptoms in people who are allergic
The advantage of taking Pantethine vs. Pantothenic Acid is one primary
difference and that is in the effect between pantethine and pantothenic acid.
Clinically, it is with regard to lipid lowering activity. Pantethine has been
shown to have several lipid lowering effects while pantothenic acid does not
appear to have these effects.
Pantethine in a dose of 300 mg three times daily has been shown to significantly
reduce serum triglycerides, total cholesterol, and LDL cholesterol while raising
Pantethine was especially effective in one study of diabetic patients on
dialysis. These patients had a reduction in total cholesterol, VLDL, and
triglycerides, although no change was noted in their HDL cholesterol. (Murray