[FONT=Arial,Helvetica]In a study involving 44 healthy premenopausal women, subjects consuming a high-fat/low-fiber diet were found to have significantly higher levels of urinary total estrogens, estriol-3-glucuronide, 2-hydroxyestradiol, 16alpha-hydroxyestrone, the ratio of 2-hydroxyestrone/4-hydroxyestrone, and catechol, as compared to subjects consuming a low-fat/high-fiber diet.
After adjusting for total fiber intake, total intake of fat was significantly associated with plasma levels of estrone, estradiol, urinary levels of 2-hydroxyestrone, 2-hydroxyestradiol, the ratio of 2-hydroxyestrone/4-hydroxyestrone, and total urinary estrogens. No significant difference between the groups was found for the ratio of 2-hydroxyestrone/16alpha-hydroxyestrone.
These results highlight the influence of dietary factors, specifically intake of fat, on levels of various sex hormones in premenopausal women.[/FONT]