Brain wasting or atrophy is a common sign of cognitive impairment and is closely associated with Alzheimer's dementia. The rate of brain atrophy is increased by higher concentrations of homocysteine in the blood and brain tissue. Researchers examining the results of this study found that the group, which supplemented with B vitamins for a period of two years, experienced a 30% reduction in homocysteine levels. They found dramatic improvements in mental tests including global cognition and episodic memory (69% improvement in word recall memory) compared to the control group.
The standard American diet (SAD) includes large quantities of oxidized omega-6 fats from fried and processed foods when compared to omega-3 fat consumption (from fish, nuts and seeds). The ratio of omega-6 to omega-3 fatty acids ranges from 20:1 to as high as 50:1 (ideal range is no more than 4:1), creating a perpetual degree of inflammation throughout the body. Researchers have determined that this imbalance creates a disturbance in brain chemistry affecting neurotransmitter balance and electrical firing in the brain that sets the stage for amyloid tangles and cognitive decline.
Reestablishing omega fat homeostasis by balancing toward a 1:1 intake ratio and by correcting B vitamin nutritional deficiencies provide deep insight toward understanding and controlling the development of many forms of dementia including Alzheimer's disease. Most middle aged adults will want to include a high potency B vitamin supplement (preferably formulated from natural food sources) and to include omega-3 fats from diet or fish oil consumption to lower dementia risk factors.