Resveratrol vs. Breast Cancer

[Harry Hirsute]

This is highly preliminary but promising.

For the current study, Rogan and colleagues measured the effect of resveratrol on cellular functions known to contribute to breast cancer.

The formation of breast cancer is a multi-step process which differs depending on type of disease, a patient's genetic makeup and other factors. However, scientists know that many breast cancers are fueled by increased estrogen, which collects and reacts with DNA molecules to form adducts. Rogan and colleagues found that resveratrol was able to suppress the formation of these DNA adducts.

"This is dramatic because it was able to be done with fairly low concentrations of resveratrol to stop the formation of these DNA adducts in the cells we studied," said Rogan. Although researchers experimented with up to 100 �mol/L of resveratrol, the suppression of DNA adducts was seen with 10 �mol/L. A glass of red wine contains between 9 and 28 �mol/L of resveratrol.

The researchers also found that resveratrol suppressed the expression of CYP1B1 and the formation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, two known risk factors for breast cancer.

Rogan said resveratrol works by inducing an enzyme called quinone reductase, which reduces the estrogen metabolite back to inactive form. By making estrogen inactive, resveratrol decreases the associated risk.

The current study was conducted in laboratory cultures, and will need to be confirmed in larger human trials, Rogan said.

http://www.eurekalert.org/pub_releas...-ric063008.php