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Old 03-06-2008, 10:42 AM
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Default Chromium Picolinate May Stimulate Activity in Older Brains

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The new study, which included about 30 people, adds to a growing body of science reporting potential health benefits of chromium picolinate, most notably for blood sugar control in diabetics.

The full data from the randomised, double-blind, placebo-controlled study have not been seen by NutraIngredients.com. However, the results have been presented at two peer-review medical conferences.

Chromium is an essential trace mineral that occurs naturally in small amounts in some foods, including brewer's yeast, lean meat, cheese, pork kidney and whole grain bread and cereals. It is poorly absorbed by the human body but is known to play an important role in the metabolism of carbohydrate, fat and protein.



Several reports have indicated that chromium picolinate is better absorbed by humans than other forms of the mineral.

Krikorian and co-workers looked at a subset of 13 older adults (average age 72.5) with signs of early memory decline and randomly receiving the chromium picolinate supplement or a placebo for 12 weeks. Brain activity was measured using fMRI while the participants worked on a challenging cognitive task that involved holding in mind and manipulating visual information.

According to the researchers, the fMRI scans showed an increase in activation in right thalamic, right temporal, right posterior parietal and bilateral frontal regions in participants receiving chromium picolinate.

"These brain imaging results support findings from the prior study suggesting that chromium picolinate may be beneficial for older adults with early memory decline and metabolic irregularities, factors that substantially increase the risk for dementia," said Krikorian.

"These findings substantiate the need for continued research to determine the nature and extent of this enhancement," he added.

The research was welcomed by James Komorowski, vice president of scientific affairs at US-based Nutrition 21, which makes the picolinate form of chromium. "The earlier memory study conducted by the University of Cincinnati team in addition to the current data using functional MRI supports the ability of chromium picolinate to help improve working memory in the elderly," said Komorowski.

Nutrition 21 provided both the chromium picolinate and funding for the study.
http://nutraingredients.com/news/ng....brain-activity
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Old 04-14-2008, 08:04 AM
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This actually conflicts with research I read about 4-5 years ago.

In the early days of CP back in 1991, it was touted as a do anything muscle building, fat burning wonder stuff, and wasn't.

In 1996, it was labelled as false and most manufacturers if not all, forced legally to have all such irrelevant claims / benefits, taken away from packaging.

In 2001, independant science showed a possible link between CP and Genotoxicity, (Mutation of Human DNA). I have read reports since of people using it and getting hairloss.

It also caused Ovarian Cancer in Hamsters.

This represents an interesting dilemma, based on the premise it caused Cancer to living tissues.

1. If the dose was scaled down from a human dose, in comparison to an average humans body mass and a Hamsters, similar effects might be possible in humans long-term, or in a similar timeframe.

2. If the dose was a full human dose, then the magnification of rodent tissue damage, could indicate no serious, (if any), risk to humans.

The independant science was verified and approved, by a leading scientist called Dr Ann De Weiss Allen, who amongst other things has been a medical proffessional at the time for 20 years, and worked in the field of Cancer for 5 years. She'd also designed nutrition plans for 2 miss Galaxy competitors, and Arnie S, as a side note and apro pro of nothing.

The tests as I rememebr reading, were performed on 3,000 subjects with doses simulating a 5 year period.

The science then prompted a CP manufacturer Nutrient 27, to cry foul.

They claimed their own tests proved no links to Genotoxicity, or any other possible issues, but their tests were far from adequate.

1. They only used 1,000 subjects not 3,000.

2. The subjects were split into control groups, of 3 months, 6 months and 12 months. No eveidence of how many were in each, was noted in my observation of the article, so possibly only 10 stayed the full distance or 100, or 500, I don't know.

3. The doses given were never stated.

The evidence since, has hinted at a U-turn on the Genotoxicity theory, but I don't recall seeing anything concrete to totally blow that idea, but I have still seen people in the past claiming hair loss, and then no more hair loss upon stopping use.

I saw a few too many of those claims, by non-biased messageboard users to dismiss it as coincidence.

The fact is, the Piicolinic Acid breaks off the bond and Oxidses in the Liver, the Chromium, is not the potential problem.

So the answer is, why use CP, when there are other forms like Polynicotinate, Nicotinate and Chromate?

Also I would say there is potential risk in taking Zinc Picolinate, for the same reason, by being a Picolinate, it must surely contain Picolinic Acid, therefore be a possible problem.

Incidentally a company called Maximuscle UK, brought a product out some time back, that was an all in one called Cyclone. I nearly bought it once until I found out about the CP risks. It was a typical Protein, Creatine, Glutamine product with CP, and I think also with HMB.

Since then, I see the CP has been replaced with another Chromium type, so maybe they were concerned about it too.

I haven't actually used an all in one anyway before or since that decision, as I now realise they claim to be cheaper than buying all the ingredients seperately, but possibly not if you just go for the main 3, Protein Creatine and Glutamine, and ignore additional things like Chromium and HMB, and also all-in one products offer less flexibility in my mind.

P.S. the original study verified by Dr Allen may still be around on the net somewhere.

Last edited by Boss; 04-14-2008 at 08:09 AM.
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Old 04-14-2008, 08:59 AM
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I use:
GTF Chromium (as polynicotinate) ChromeMateŽ200 mcg

I can't remember why.
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