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Old 03-05-2008, 08:31 PM
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Default Study finds bacteria may reduce risk for kidney stones

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Study finds bacteria may reduce risk for kidney stones
Researchers from Boston University’s Slone Epidemiology Center have found that the bacteria Oxalobacter formigenes (O. formigenes), a naturally occurring bacterium that has no known side effects, is associated with a 70 percent reduction in the risk of recurrent kidney stones. These findings appear online in the March issue Journal of the American Society of Nephrology.
Kidney stones are an important health problem in many countries. In the United States, the lifetime risk for developing a stone is five to 15 percent, and a five-year risk for recurrence is 30 to 50 percent. The economic impact of hospital admissions for this condition is $2 billion per year.

According to the researchers, up to 80 percent of kidney stones are predominately composed on calcium oxalate (CaOx) and urinary oxalate is a major risk factor for CaOx stone formation. O. formigenes metabolizes oxalate in the intestinal tract and is present in a large proportion of the normal adult population.

Data was collected in the Boston, Massachusetts and Durham, North Carolina areas from 247 adult patients with recurrent CaOx stones and compared with 259 age, sex, and region-matched controls. O. formigenes colonization was determined by culture of stool samples. Information was obtained by interview and self-administered dietary questionnaire. 24-hour oxalate excretion and other urinary risk factors were measured in a subset of 139 cases and 138 controls. The prevalence of O. formigenes was 17 percent among cases and 38 percent among controls, giving an odds ration of 0.3. The finding was consistent in subgroups defined according to age, sex, race, region and antibiotic use.

“We observed a strong inverse association between colonization with O. formigenes and recurrent CaOx kidney stones, with a 70 percent reduction in overall risk,” said lead researcher David Kaufman, ScD, a professor of epidemiology at Boston University School of Public Health. “Our findings are of potential clinical importance. The possibility of using the bacterium as a probiotic is currently in the early stages of investigation,” added Kaufman.
http://www.physorg.com/news123944082.html
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Old 03-05-2008, 08:53 PM
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Some Antibiotics Exacerbate The Formation Of Kidney Stones
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Intestinal Oxalobacter Formigenes Colonization Urinary Oxalate Levels in Calcium Oxalate Stone Formers

It is known that oxalobacter formigenes is a colonic bacterium capable of breaking intestinal oxalate. This study showed that there is a correlation between calcium oxalate stone formers and the absence of oxalobacter formigene colonization. Patients who form calcium oxalate stones, who lack oxalobacter have a higher average urinary oxalate level than patients who are oxalobacter positive. The authors suggest that patients taking quinolones will reduce the level of oxalobacter formigenes, while patients taking penicillin or Bactrim do not have any effect on the oxalobacter formigene level. They recommend giving penicillin or Bactrim to the patients who are calcium oxalate stone formers.

Troxel SA, Low RK. Intestinal Oxalobacter Formigenes Colonization Urinary Oxalate Levels in Calcium Oxalate Stone Formers. Journal of Urology 165:245A, 2001.



Can the Recurrence of Oxalate Stone be prevented? Role of Oxalobacter Formigenes in Stone Recurrence.

90% or urinary calculi are calcium oxalate stones. Oxalobacter formigenes is a oxalate degrading bacterium, colonizing the GI tract in humans. This study demonstrated a relationship between urinary oxalate levels and the intestinal bacterium, oxalobacter formigenes. The absence of the bacterium in the intestines appears to result in a higher risk of recurrent oxalate stone disease by causing hyperoxaluria.

Tunuguntla HSGR. Can the Recurrence of Oxalate Stone be prevented? Role of Oxalobacter Formigenes in Stone Recurrence. Journal of Urology 165:246A, 2001.
http://www.urologystone.com/CH18WhatsNew/2001AUA.html
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