traditional dietary recommendations of limiting fat while favoring dietary carbohydrates may be a suboptimal strategy for improving nearly every metabolic risk factor for breast cancer recurrence, including decreasing adipose tissue, serum glucose, serum insulin, and inflammatory factors, while increasing HDL and insulin sensitivity.
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While the paper is discussing the diet in relation to Breast Cancer prognosis the ideas being discussed would be equally suitable for breast cancer progression.
Fat cells secrete the inflammatory mediators tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), and retinol-binding protein-4 (RBP4). TNFα has been shown to promote breast cancer growth through the activation of several intracellular molecular pathways, including MAPK, kappa B (NF-kappa B), and the PI3-K/Akt pathway
IL-6 was independently correlated with shorter survival
IL-6 was also found to be predictive of nodal involvement, tumor size at initial diagnosis, progression, and experiencing multiple metastatic sites
circulating levels of CRP and serum amyloid A were associated with reduced disease-free and overall survival.
High levels of these inflammatory markers were also associated with a doubling of the risk of recurrence and mortality in a cohort of women diagnosed with breast cancer