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Old 12-13-2007, 11:35 AM
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Default Chromium Picolinate May Aid Cognitive Function



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The randomized, double-blind, placebo-controlled study measured whether supplementation with chromium picolinate over a 12-week period might improve cognitive function in 21 adults aged 65 years and older with early memory decline.

Study participants were asked to learn a list of words presented over several learning trials and, after a delay, were asked to remember the words. Those receiving the chromium picolinate supplement showed a trend for reduced interference from irrelevant words on the memory task (p = 0.12).



In addition, on another task assessing fine motor control and speed, the subjects receiving chromium picolinate exhibited enhanced motor speed relative to those receiving placebo (p = 0.16).

Another component of the study measured brain activity. Functional magnetic resonance imaging (fMRI) scans were performed while subjects were working on a demanding cognitive task that involved holding in mind and manipulating information.

Preliminary results from the fMRI scans of individuals from the chromium picolinate group and from the placebo group showed that the subjects receiving the active supplement exhibited greater activity in left frontal and left parietal cortices, areas of the brain associated with working memory. The subjects receiving placebo showed no such change.

At the completion of the study, chromium to creatinine ratios were significantly elevated in the chromium picolinate group (p = .008) indicating increased levels of chromium in the blood. The groups did not differ significantly with respect to age (73 versus 69 years), educational level (15.7 versus 15 years), stage and extent of memory impairment (Clinical Dementia Rating sum boxes score, 1.0 versus 0.85) or level of mood disturbance (Profile of Mood States total score, 18.4 versus 16.9).
http://www.eurekalert.org/pub_releas...-ncd121207.php
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Old 12-13-2007, 12:41 PM
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Default Probability question

I don't really understand what is being claimed in all referenced tests,
but in particular and for example take the following:

"In addition, on another task assessing fine motor control and speed, the subjects receiving chromium picolinate exhibited enhanced motor speed relative to those receiving placebo (p = 0.16)"

I feel sort of stupid because I don't know what to make of the statement
above. I can't figure out exactly what they are doing. And I don't know
how the probability expression p=0.16 applies.

Would sure appreciate being educated!
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Old 12-13-2007, 01:02 PM
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Don,

The study doesn't appear to be available (at least not on PubMed or on the Nutrition 21 web site).

There is however a contact person on the press-release ... accessible from the link provided in my first post.

Perhaps you can formulate your specific questions (and e-mail them) and see if the rep can provide satisfactory answers or at least a copy of the study.
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Old 12-14-2007, 02:56 PM
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I did find this, on another site (below). It doesn't answer your question, Don, but it does identify the dosage of chromium used in the study.

Quote:
The New York State-based developer and marketer of chromium and omega-3 fish oil-based dietary supplements presented results of a clinical study showing that daily supplementation with 1,000mcg chromium as chromium picolinate improved cognitive function in older adults experiencing early memory decline. The results of the randomized, double-blind, placebo-controlled study were presented to the medical community at a neurological meeting.

Chromium picolinate has been used in supplements for weight management and diabetes because it increases glucose metabolism, but the new findings add clout to applications for cognitive health.

"Ultimately, we may find that chromium supplementation offers benefit to patients, given the prevalence of metabolic disorders and associated cognitive decline in the aging population," said Robert Krikorian, lead investigator and associate professor at the University of Cincinnati College of Medicine's department of psychiatry.

Chromium is an essential trace mineral that occurs naturally in small amounts in some foods, including brewer's yeast, lean meat, cheese, pork kidney and whole grain bread and cereals. It is poorly absorbed by the human body but is known to play an important role in the metabolism of carbohydrate, fat and protein.
http://www.nutraingredients-usa.com/...nnati-chromium
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