Go Back   Natural Medicine Talk > Health > Diabetes

Reply
 
Thread Tools Display Modes
  #1  
Old 09-15-2007, 04:52 PM
Harry Hirsute's Avatar
Harry Hirsute Harry Hirsute is offline
Lecturer
 
Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,840
Harry Hirsute will become famous soon enough
Default Milk Thistle and Diabetes

Quote:
Small Study Shows that Adding Silymarin to Conventional Therapy for Type 2 Diabetes May Improve Glycemic Parameters

Huseini HF, Larijani B, Heshmat R, et al. The efficacy of Silybum marianum (L.) Gaertn.

(Silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2006;20:1036-1039.



Milk thistle (Silybum marianum) seed extract contains flavonolignans called silymarin. Silymarin has powerful antioxidant properties. Oxidative stress has been implicated in the pathogenesis of diabetes. The purpose of study was to evaluate the effect of silymarin on the glycemic profile in patients with diabetes.

Patients (n=51) of the Shariati Hospital, Tehran, Iran, with type 2 diabetes participated in this randomized, double-blind, placebo-controlled trial. Patients received either placebo or a 200 mg silymarin tablet (Institute of Medicinal Plants, Tehran, Iran) 3 times per day before meals for 4 months. In both groups, patients continued on conventional oral hypoglycemic agents. Blood samples were analyzed.

At baseline, there were no significant differences between groups, with the exception of triglyceride levels. The average fasting glucose and HbA1C (average glycosylated hemoglobin) levels significantly decreased after 4 months in silymarin-treated patients (156 to 133 mg/dL and 7.8 to 6.8%, respectively; P<0.001) and significantly increased over time in placebo treated patients (167 to 188 mg/dL and 8.3 to 9.5%, respectively; P<0.0001).

Silymarin treatment also significantly lowered blood levels of total cholesterol, lower density lipoprotein (LDL) cholesterol, triglyceride, liver enzymes (SGOT and SGPT).

The mechanism of action for the aforementioned benefits is not known. It is hypothesized that silymarin induces a positive effect on diabetic metabolic abnormalities through its antioxidant activity.

The authors conclude that adding silymarin to conventional therapy reduces in the glycemic state in patients with type II diabetes. A large, multicenter study is needed to verify the findings.

Heather S. Oliff, PhD
http://content.herbalgram.org/iherb/...ew.asp?i=44940
Reply With Quote
Reply
Please reply to this thread with any new information or opinions.

Thread Tools
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Milk Thistle for Pets kind2creatures Pet Health 1 06-24-2010 06:13 AM
Milk Thistle Complex vs. Hepatitis C Harry Hirsute Systems & Organs 6 02-10-2009 11:38 AM
Milk Thistle - Liver Protector & Cancer Fighter Harry Hirsute Cancer 1 09-19-2008 10:35 AM
Rosacea - Topical Milk Thistle and MSM Harry Hirsute Skin Health 1 02-10-2008 09:53 PM
Skim milk more fattening than whole milk! bifrost99 Exercise & Dieting 2 07-23-2006 02:35 PM