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Old 01-15-2012, 06:12 PM
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Default Antifungal Drug Nizoral Lowers PSA In Study..

http://www.freepatentsonline.com/y2005/0049207.html


The PSA is a 33-kDalton serine protease inhibitor made by the Ascomycete fungi, Aspergillus flavus, Aspergillus fumigatus, Aspergillus oryzae, Ophiostoma piceae, and Scedosporium apiospermum. An elevated PSA is seen not only in men with prostatic disease, but also in women with breast, ovarian, pancreatic, and colon cancer; and even in women during pregnancy.


There has been much, recent confusion on exactly what is the role of the prostate specific antigen (PSA) in screening for and following the course of prostate cancer. Up to 50% of the time, a “positive” (high) PSA level, upon further, biopsy evaluation, does not correlate with prostate cancer. If PSA screens for fungus, then PSA levels should decrease with antifungal therapy, hence:
  • Mann, D. Antifungal agent lowers PSA levels, study finds. May 1, 1997. p6. Medical Tribune.
The antifungal drug, Nizoral® (ketoconazole) lowered PSA levels in men with prostate cancer. It was suspected that ketoconazole's ability to increase estrogen levels, via inhibiting the breakdown of estrogen in the liver in men, was the mechanism for this lowering effect. However, if indeed a high PSA signals a fungal infection gone awry, then the antifungal effect of ketoconazole should be the obvious reason for the lowering of the PSA.

Mycotoxicoses are not Rare, as is Typically Thought to be the Case.

A. Examples of Cancer Being Treated and Recurrences Being Prevented by Antifungal Measures, Using Both a Low-Carbohydrate Diet and Natural/Prescriptive Antifungals

1. A 62 yr. old female who had a history of hormone replacement therapy (HRT) use for 14 yrs, as well as a history of recurrent tonsillitis, treated with antibiotics, was diagnosed with “aggressive breast cancer” upon biopsy of a lump discovered by her and her doctor in April of 1999. The risk of fungal and yeast overgrowth following the use of estrogen, progesterone, and antibiotics is well documented.

Her cancer was negative for estrogen receptors. Her recommended course of treatment by one oncologist was chemotherapy, surgery and radiation. Another oncologist recommended at least surgery and radiation. She had a lumpectomy done in April of 1999. Greater extension of the mass was noted at the time of surgery, so she underwent a complete mastectomy in May of 1999. She had 10 lymph nodes removed, which were all free of cancer.
She opted not to follow up with chemotherapy and radiation, against the advice of her oncologists, and made some lifestyle changes instead. These changes consisted, in part, of a low-grain diet (high in vegetables, fish, nuts, some fruits, and meats) that she began to follow. She had a PET scan done in early 2003 and showed no recurrence of cancer.

2. A 68 year old male with a history of diabetes (diagnosed 5 yrs prior to the cancer) and a 30 year history of smoking (pipe and cigars).
He began eating a 5 pound bag of in-the-shell peanuts every week starting in 1997. By February of 2000, he notice large, marble sized lumps in his neck. He went to the VA Hospital in St. Petersburg, Fla., where, upon biopsy and pathological evaluation, it was suspected that he had cancer of the lymphoma type. The specimen was sent to a lab at the National Institutes of Health, where “Large B-cell Lymphoma” was verified. No other sites of cancer were detected upon radiologic evaluation—his chest and abdomen were free of any discernable masses.

The treatment recommended by his oncologists was surgery, chemotherapy, and radiation. He and his wife decided to do none of these. Having heard of the aflatoxin contamination potential in peanuts, his wife took him off all peanuts and peanut products and began to follow a low-grain diet. In addition, she place him on several, natural antifungal substances, such as Silymarin (milk thistle), Essiac tea (an herbal tea blend), an “anti-plague formula” (an aged, extract of a blend of fresh onions, garlic, horseradish, ginger, vodka, hot peppers), Garlic, vitamin C, and many herbs exhibit well documented antifungal effects.

Upon instituting these lifestyle changes, the masses in his neck began to “soften” within a week, and they completely resolved within a month. They have yet to recur in over 3 years since.

3. A 49 year old female with a strong family history of various types of cancer. Her history includes a brief use of oral contraceptives in her 20's, as well as some complications that followed her pregnancy in 1991 which were as follows: she had slow progression of her labor (over 3 days), prolonged rupture of her membranes, which always spurs the use of prophylactic antibiotics, and an eventual, emergency C-section.
One month after her pregnancy, her ankles began to swell. This spontaneously resolved, but returned in September of 1991. Initially this was treated with Amoxicillin, but upon further analysis, it was found that she had a type of kidney disease known as glomerulonephritis. In addition, she had congestive heart failure and an enlarged liver. Subsequently, she was on prednisone for 3 years (for treatment of the kidney disease) as well as cytoxan, diuretics, coumadin, and various, other drugs
.
The potential for opportunistic fungal infections to take hold during times of treatment with antibiotics and corticosteroids is well documented.
She was able to wean off of the steroids after 3 years.

By 2001, she was diagnosed with colitis and irritable bowel syndrome. Intestinal dysbiosis due to antibiotic use is also well documented.
In October of 2001, she passed out due to severe anemia. At her doctor's, her hemoglobin was found to be less than 4 g/dl. She was referred to the hospital and had a blood transfusion. In the search for the etiology of her anemia, a very large, intestinal mass was discovered both on exam and radiologic workup. Undergoing surgery, she had a large, grapefruit-sized mass, along with a portion of her small intestines, removed. Pathological evaluation of the mass revealed “moderately to poorly differentiated adenocarcinoma versus malignant carcinoid tumor, with extension into the intestinal adipose tissue.” Three out of nine lymph nodes removed from the abdominal cavity were also positive for cancer involvement.
Adjuvant therapy recommended by her surgeon and oncologist was combination, low dose chemotherapy.



Instead of doing chemotherapy, she decided—against her doctors' advice—to follow a low-carbohydrate diet and take various, natural antifungal substances—caprylic acid and garlic. In addition, she took shark cartilage, which has anti-angiogenesis properties.
By December of 2001, her blood and tumor markers were normal, and remain so almost 3 years later.

4. A 60 year old man was diagnosed as having prostrate cancer. UTSW study for BPH ×5-6 yrs. Biopsy prior and post program. Normal PSA! At post-study diagnosis, cancer was found: October 2001. He moved to OKC and started watching Doug's show.
Past history includes heavy use of antibiotics, recurrently for allergies, sinusitis.

Went to MD Anderson—found cancer in different place of the prostate, but Cancer was confirmed nonetheless. Gleason stage 7.
Started on Phase I for 2 months (had severe die-off ×4 days—including fever), nystatin thereafter ×2 months. Cont'd diet for 4 months and stays on a variant of the diet. On UGN, Caprylic acid, GSE now ×3 months. Saw John Hogan, D.O. (OKC). Past 2 yrs: PSA now is 1.1. Was closer to 4.0 at the time of cancer diagnosis.

F/U Ultrasound: cannot find any tumors. Whole body scans have been negative.
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Old 01-15-2012, 09:10 PM
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The drug is called ketaconazole that is in nizorale.
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Old 01-16-2012, 07:21 AM
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That is very good to know. As technology advances, we should be better able to determine if our diagnosed cancer is fungus induced or virus induced. Even break it down further to determine what type of fungus induced the cancer, or whether it was induced by RNA-containing virus, or DNA-containing virus. Even bacterial induced cancer, such as h.pylori causing gastric cancer.

Diagnosis is the key. The industry is maturing.
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Old 09-03-2012, 04:04 AM
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Interesting tutorial on pH, bacteria, fungus and cancer;

http://biomedx.com/microscopes/rrintro/rrintro.html
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