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Old 07-30-2008, 12:32 PM
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Default Boswellia Extract May Safely Combat Arthritis Symptoms

July 30, 2008

5-LoxinŽ rapidly improves arthritis symptoms

An article published online on July 29, 2008 in the journal Arthritis Research & Therapy reported the finding of researchers at the University of California, Davis of significant and rapid improvement of osteoarthritis symptoms in patients treated with the herb Boswellia serrata.

Boswellia serrata, also known as frankincense, has been used for thousands of years in Indian Ayurvedic medicine, and has become popular in western countries among individuals desiring to use nontoxic arthritis remedies.

For the current randomized, double-blinded trial, Siba Raychaudhuri and colleagues used a formulation called 5-LoxinŽ, which is an extract of Boswellia serrata enhanced with 30% 3-O-acetyl-11-keto-beta-boswellic acid (AKBA, the plant's most active ingredient).

Seventy patients who had been treated for osteoarthritis with nonsteroidal anti-inflammatory drugs prior to the study were divided to receive 100 or 250 milligrams 5-LoxinŽ per day, or a placebo for 90 days. Participants were evaluated after 1 week and at the end of each month until the study's conclusion, during which blood samples were collected and assessed for proinflammatory and toxicity indicators. Matrix metalloproteinase-3, an enzyme involved in joint damage, was measured in knee synovial fluid at the beginning and end of the study.

As early as 7 days after beginning treatment with high dose 5-LoxinŽ, participants reported improvements in pain and functional ability. By the end of the study, both low and high dose-LoxinŽ were associated with pain and function improvement, and synovial fluid matrix metalloproteinase-3 was reduced. No adverse treatment effects were noted.

"The high incidence of adverse affects associated with currently available medications has created great interest in the search for an effective and safe alternative treatment," Dr Raychaudhuri stated, "AKBA has anti-inflammatory properties, and we have shown that B. serrata enriched with AKBA can be an effective treatment for osteoarthritis of the knee".

—D Dye
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