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Old 03-27-2008, 10:00 AM
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Harry Hirsute Harry Hirsute is offline
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Default Curcumin May Aid in Brain Regeneration

This is obviously very preliminary research. But it's still pretty-darn exciting if you ask me.



Quote:
J Biol Chem. 2008 Mar 24 [Epub ahead of print]

Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus.

Kim SJ, Son TG, Park HR, Park M, Kim MS, Kim HS, Chung HY, Mattson MP, Lee J.

Pharmacy, Pusan National University, Busan 609-735.

Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation.

Curcumin has been reported capable of preventing the death of neurons in animal models of neurodegenerative disorders, but its possible effects on developmental and adult neuroplasticity are unknown.

In the present study, we investigated the effects of curcumin on mouse multi-potent neural progenitor cells (NPC) and adult hippocampal neurogenesis. Curcumin exerted biphasic effects on cultured NPC - low concentrations stimulated cell proliferation, whereas high concentrations were cytotoxic.

Curcumin activated extracellular signal regulated kinases (ERKs) and p38 kinases, cellular signal transduction pathways known to be involved in the regulation of neuronal plasticity and stress responses. Inhibitors of ERKs and p38 kinases effectively blocked the mitogenic effect of curcumin in NPC.

Administration of curcumin to adult mice resulted in a significant increase in the number of newly-generated cells in the dentate gyrus of hippocampus, indicating that curcumin enhances adult hippocampal neurogenesis.

Our findings suggest that curcumin can stimulate developmental and adult hippocampal neurogenesis, a biological activity that may enhance neural plasticity and repair.
http://www.ncbi.nlm.nih.gov/pubmed/18362141
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Old 03-27-2008, 06:57 PM
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I would think they should be able to see some consequence of this in the Indian population vs US? because curcumin is such a regular part of the Indian diet?

well.. think I will start making curry again.

for those of you that are into quick fix foods.. I would recommend this paste.
http://www.maesribrand.com/VacuumPack400.htm

my favorite is the panang curry paste. add it to coconut milk (did you hear that, Harry?), and pour over chicken that has been stir fried with ginger and garlic. very tasty.

the red curry paste is good too. the green curry, good.. but HOT!!

maesri makes one serving cans, so you can try different flavors easily. If you don't like it, you don't have a bunch left over. very nice.

here are some recipes for Thai curry:
http://www.grubshack.com/essays/thai-curry2.html
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Old 04-01-2010, 09:50 PM
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This was posted in an Alzheimer's post also but I think it has more widespread benefits and wanted to capture it here. I think one could do this easily with eggs (with lecithin, which has choline, and some dha depending on the amount of omega 3) and a source of uridine. They say uridine cannot be obtained from foods, but it can according to Wiki-

Uridine is a molecule (known as a nucleoside) that is formed when uracil is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond.
If uracil is attached to a deoxyribose ring, it is known as a deoxyuridine.
Sugarcane extract is rich in nucleosides, especially uridine.
Combine this with tumeric (source of circumin) and one would think it could really do some good in the brain.
**********************
In the Brain Research paper, the MIT team reported that rodents given a cocktail of DHA (a type of omega-3 fatty acid), uridine and choline showed a greatly increased concentration of dendritic spines, which receive messages in the postsynaptic neuron. That indicates that synapse regeneration has occurred, which is unusual, Wurtman said.

Synapse regrowth could also prove an effective treatment for other brain diseases, such as Parkinson's, or for brain injuries, he said.

The researchers found that rodents who received the treatment performed much better on tests of cognitive ability (specifically, navigating a water maze). Sarah Holguin, an MIT graduate student in brain and cognitive sciences, presented those results at the Society for Neuroscience annual meeting earlier this month.

Some of the rats in the studies received all three compounds and some received only one. The improvements in synapse growth and cognitive ability were greatest in the rats given all three.

Omega-3 fatty acids are not produced in the body but are found in a variety of sources, including fish, eggs, flaxseed and meat from grass-fed animals. Choline can be synthesized in the body and obtained through the diet; it is found in meats, nuts and eggs. Uridine cannot be obtained from food sources, but is a component of human breast milk and can be produced in the body.

weblink:www.physorg.com/news115316813.html
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Old 04-16-2010, 11:54 PM
SilviaMercedes SilviaMercedes is offline
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This is fascinating!

I read something similar about Blueberries (that they help to regenerate brain cells).

Thank you so much for sharing this!

Quote:
Originally Posted by Harry Hirsute View Post
This is obviously very preliminary research. But it's still pretty-darn exciting if you ask me.



http://www.ncbi.nlm.nih.gov/pubmed/18362141
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Old 10-20-2010, 11:56 AM
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there's all sorts of spices, herbs and tools that can stimulate the brain. this is nothing new in my opinion but thanks for the link.

I believe exercise can also enlarge the size of the adult hippocampus. Exercise is an excellent way for brain regeneration as the release of hormones and chemicals affects the neuro-transmission patterns in the brain.
besides that, supplements like PhosphatidylSerine, Omega 3 in fish oil and the rest of it are other ways to boost brain performance and regeneration.
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Old 10-26-2010, 06:25 AM
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Quote:
Originally Posted by scorpiotiger View Post
I would think they should be able to see some consequence of this in the Indian population vs US? because curcumin is such a regular part of the Indian diet?

well.. think I will start making curry again.

for those of you that are into quick fix foods.. I would recommend this paste.
http://www.maesribrand.com/VacuumPack400.htm

my favorite is the panang curry paste. add it to coconut milk (did you hear that, Harry?), and pour over chicken that has been stir fried with ginger and garlic. very tasty.

the red curry paste is good too. the green curry, good.. but HOT!!

maesri makes one serving cans, so you can try different flavors easily. If you don't like it, you don't have a bunch left over. very nice.

here are some recipes for Thai curry:
http://www.grubshack.com/essays/thai-curry2.html
There is less alzheimers and less breast cancer in the Indian population and they do think it is due to the turmeric. Both indian curries and thai curries do kick ass. And my rule is "the hotter, the better". It is only worth eating if your head is sweating after the meal.
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Old 10-26-2010, 06:27 AM
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http://www.wellnesstrader.com/eviden...ric-Alzheimers
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Old 10-31-2010, 09:32 AM
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Here is the full text of the paper the above article was based upon.
The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse Bear in mind that was nearly 10 years ago and much has happened since then to confirm the benefits of curcumin.

The full text of this article is available online,
Why Pleiotropic Interventions are Needed for Alzheimer's Disease and it has a long section on the different ways curcumin may be working to prevent Alzheimer's. They also spend time discussing the benefits of the omega 3 component DHA from fish oil. What both DHA and curcumin have in common is that they BOTH can activate the Vitamin D receptor and both work in synergy with Cholecalciferol (vitamin D3). However I wouldn't want anyone to JUST use curcumin or just use vitamin D3 or just use DHA. They know that different gene groups work better with one than the other so as it's almost impossible or would be very expensive to get your genes tested to find out if your potential for Alzheimer's was best reduced by one or other of the threesome it's cheaper and safer to make sure you have adequate amounts of each available.
As far as the omega 3 DHA is concerned readers have to be aware that current levels of omega 6 from industrial seed oils particularly soya, but also corn, sunflower, safflower cottonseed etc are so high that they displace omega 3 from it's position in the cells. So whatever intake of omega 3 you will will be futile if it cannot get into and maintain is position in your cells. So fundamental to considering your omega 3 status is the elimination of soyabean, corn and sunflower and the like industrial seed oils and all the foods that contain them. You also have to understand that most US adults have about 30 times too much omega 6 and far too little omega 3. The half life of omega 6 in the body is roughly 2 yrs so stopping all unnecessary additional omega 6 intake while increasing omega 3 (ideally around 2g of EPA + DHA daily) will see a measurable difference in plasma levels within a fortnight but it will be 2yrs before that makes a noticeable difference to cell levels and it could be 5 yrs before you get back to the omega 3 omega 6 ration around 1<> 1 or at least around 1 omega 3 <> to below 5 omega 6. Around that level the omega 3 can hold it's own but above that level more omega 6 = less omega 3.
There is a bit of a bioavailability issue with curcumin and it's thought that much of the plain dietary form is not absorbed, although clearly it's probable that the daily use of curcumin by asians who continue to eat traditionally when living at high latitude than originally does seem to protect them to some extent from the vitamin D deficiency common at higher latitudes. But people who are unlikely they will be consuming turmeric spiced foods all day every day may appreciate knowing.
Life Extension, Super BIO-Curcumin
Doctor's Best, Meriva, Phytosome Curcumins
Are forms that have been devised to make the uptake more effective.
As for DHA I use a liquid fish oil such as
Nature's Answer, Liquid Omega-3, Deep Sea Fish Oil EPA/DHA because each teaspoon provides EPA (Eicosapentaenoic Acid) 800 mg DHA (Docosahexaenoic Acid) 500 mg = 1300mg so just under 2 teaspoons gets me over the 2g daily amounts. and being a liquid fish oil I can taste if it's beginning to go off and tastes rancid.
I find keeping the bottle in the fridge and only taking it out of the fridge while I am using it and putting it straight back before it reaches room temperature seems to work fine for me.
There are high strength alternative capsules
Now Foods, Ultra Omega-3, 500 EPA/250 DHA
Omega-3 Fatty Acids 750 mg Eicosapentaenoic Acid (EPA) 500 mg
Docosahexaenoic Acid (DHA) 250 mg that mean you can manage with 4 capsules daily
Similarly with Vitamin D3 taking less than 5000iu/daily like Country Life, Vitamin D3, 5,000 IU, is unlikely to raise 25(OH)D levels into the range at which D3 is stored in cells.

Ideally you need to be around 60ng/ml and that probably requires around 1000iu/daily for each 25lbs you weigh but regular 25(OH)D testing will show how much daily your body requires to keep at a natural vitamin D status.

Because these are supplements that the body requires daily to maintain adequate status we have to understand this means a lifetime commitment or investment in health which is why it's important to look for the cheapest source, including shipping charge to your location. Which is why I use IHERB and suggest to people they also share their IHERB rewards codes like mine WAB666 so new users to IHERB enjoy a $5 discount why the regular users benefit for extra bonus discounts. Helping others by making the regular use of effective strength and forms of supplements affordable should be encouraged wherever possible. UK readers have also to take into account the fact customs adds VAT to orders over 18 value and our PO adds a 8 handling charge. So if your order comes to more than 18 before shipping charge added you may do better to use DHL shipping as their handling fee for collecting the tax is just 1.25.
US readers should shop around as your total cost will vary depending on the delivery charge and other online discount providers will vary.
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Old 10-31-2010, 10:20 AM
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I was just looking into breast cancer in the population of India.
Recently it has been sky rocketing! they think that it has to do with the recent addition of chemicals into the society although they are not sure just what chemicals.. agriculture? industry? more autos? more refined food?

India was notoriouly low in breast cancer and colon cancer and they still are in colon cancer... buy the way, Indians drink a lotta lotta milk, and eat much less meat than we do....for ages and ages... so that kind of discredits milk as causing breast cancer.... but I am highly suspicious of any product that has added estrogenic hormones. Its pretty easy to find milk that states on the label the non use of hormones these days.

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Old 10-31-2010, 11:38 AM
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this article details the INCREASE INCIDENCE RATE for BC in INDIA.
The key sentence in this article is
Quote:
India is rapidly stepping towards industrialization vis--vis urbanization resulting in change of lifestyle factors. These factors possibly contributed to a gradual increase in the incidence of breast cancer in the country.
and I have highlighted the word URBANIZATION. I'm sure everyone here is aware that urbanization leads inevitably to a decrease in Vitamin D status because urbanization inevitably leads to higher atmospheric pollution levels and lower UVB penetration to ground level so lower possibility of making vitamin D and greater reflection of UVA from hard surfaces inevitably causes amplification of the vitamin D degrading UVA element.
Vitamin D Prevents Cancer: Is It True?
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Old 12-16-2010, 02:40 PM
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Default Carcumin

The anti-inflammatory properties of this spice is thought to help fight cancer. I wasn't aware of its mental benefits. Thanks for the information article.
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Old 12-27-2010, 01:47 PM
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Pioneering Biochemist Bharat B. Aggarwal, PhD, of the M.D. Anderson Cancer Center, on Discovering Novel and Effective Cancer Treatments
By Karolyn A. Gazella
Useful information here on Curcumin, I've previously been somewhat concerned about the bioavailability of curcumin.
Maybe it's not necessary to go for the expensive forms and that the spice form is adequate.
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