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Old 10-17-2007, 11:26 AM
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Default Pycnogenol Relaxes Arteries



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The double-blind, randomized, placebo study was held at the Hiroshima University Graduate School of Biomedical Sciences in Japan. Every day for two weeks young healthy men either took 180 mg Pycnogenol or a placebo.

To identify Pycnogenol’s effect on the release of NO, an inhibitor of the amino acid L-arginine was infused in patients, which restricts the expansion of arteries in response to the neurotransmitter acytelcholine.

After two weeks of supplementation with Pycnogenol, results revealed blood flow increased in response to acetylcholine stimulation by 42 percent. In contrast, the control group receiving the placebo did not show a pronounced blood flow increase in response to neurotransmitter stimulation.

“Acetylcholine stimulates the cells of arteries to produce NO from L-arginine faster,"Dr. Higashi said. “In turn, the NO causes the muscle surrounding arteries to relax, which results in an increase of blood vessel diameters. When subjects had taken Pycnogenol the relaxation of arteries was increased by 42 percent as compared to the group taking placebo tablets."

According to Frank Schönlau, Ph.D, director of scientific communications for Horphag Research, worldwide distributors of Pycnogenol, “While more research is warranted, this is an encouraging breakthrough especially to athletes as Pycnogenol seems to allow people to move faster when exercising by satisfying the enhanced muscle oxygen demand and increasing the blood flow to active muscles.

When people are performing heavy physical activity, nerves release neurotransmitter acetylcholine to arteries supplying muscles, which makes them expand, a process that requires enhanced production of NO."
http://www.eurekalert.org/pub_releas...-nsp101707.php
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