Arrow, I say this while researching this as I have been diagnosed as bi-polar...I don't know if there is any merit to this but thought the caution was worth looking at.
Recent studies conducted by the University of Toronto found that orotic acid on its own promoted the formation of liver tumors in rats. Based on this, the European Food Safety Authority concluded that using orotate as a mineral transmitter was a safety concern. There are no long terms studies of either substance, so caution is warranted.
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