10-25-2007, 09:13 AM
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Join Date: Apr 2006
Location: Propecia, CA
Posts: 1,852
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Grapefruit and Cancer
Not too long ago, some preliminary research surfaced about the potential role that grapefruit may play in promoting breast cancer.
Here's some new research that supports the possibility that grapefruit may help to protect us from cancer.
Quote:
The new study investigated the effects of grapefruit and its active components on the activity of different enzymes in the cytochrome P450 group. These enzymes are involved in the metabolism and detoxification of many environmental carcinogens, fatty acids, fat soluble vitamins, and 60 per cent of currently-marketed drugs, stated the researchers.
Lead researcher B.S. Patel and co-workers looked at the enzyme inhibiting effects of seven different grapefruit and pummelo juices, in addition to five furocoumarins isolated from grapefruit juice - paradisin A, dihydroxybergamottin, bergamottin, bergaptol, and geranylcoumarin.
They report that both juices inhibited cytochrome CYP3A4 and CYP2C9 isoenzymes at a concentration of 25 per cent, while inhibition of the CYP2D6 isoenzyme was less at all the concentrations tested.
Moreover, paradisin A was reported to be the most active inhibitor amongst the furocoumarins. This was followed by dihydroxybergamottin, bergamottin, bergaptol, and geranylcoumarin, respectively.
"Inhibition of cytochrome P450 enzymes by grapefruit juices and its furocoumarins offers some clinical advantages in improving bioavailability of poorly absorbed drugs and reduce the dose requirements and ultimately reducing the cost and harnessing the health benefits of consuming grapefruit juice," stated the researchers.
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http://www.nutraingredients.com/news...ns-anti-cancer
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